Spatial Proteomics Service

Spatial proteomics is an advanced approach for studying how proteins are distributed, expressed, and regulated within the native architecture of tissues. Unlike conventional proteomics, which measures averaged signals from bulk samples, spatial proteomics preserves positional information, allowing researchers to investigate molecular heterogeneity across distinct cell populations, tissue regions, and microenvironments.

Our Spatial Proteomics Service provides an integrated solution for researchers seeking to characterize protein expression and localization with high spatial resolution. This service covers both discovery-driven and hypothesis-driven workflows, enabling broad proteome exploration as well as targeted analysis of predefined proteins, pathways, and post-translational modifications. By combining mass spectrometry-based imaging, multiplexed protein detection, and spatially resolved molecular mapping, we help reveal how protein networks operate in health and disease directly within intact biological samples.

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overview of Digital & Molecular Pathology Service

Our services
Workflow
Platform
Applications
Why Choose
FAQs

Our Services

Discovery Services

For broad, unbiased protein profiling and biomarker discovery.

Spatial Untargeted Proteomics Service

Targeted Analysis Services

For validation of known targets, pathways, and protein modifications.

Multiplex Imaging Services

For simultaneous visualization of multiple protein markers in tissue context.

Imaging Mass Cytometry Service

Workflow

spatial proteomics service workflow

Platform

Our laboratories are equipped with industry-leading mass spectrometry and spatial imaging technologies to guarantee high sensitivity, resolution, and reproducibility:

MALDI Mass Spectrometry Imaging (MALDI-MSI): High-throughput platforms (e.g., timsTOF fleX, RapifleX) for robust untargeted and targeted spatial mapping.
Hyperion Imaging System: The gold standard for Imaging Mass Cytometry, utilizing metal-tagged antibodies for highly multiplexed single-cell tissue imaging.
Advanced Bioinformatics Workstations: Powered by proprietary and leading commercial software for complex spatial data integration.

Applications

Biomarker discovery for identifying region-specific protein signatures associated with disease progression or therapeutic response
Pathway analysis for visualizing localized signaling networks and functional protein states within tissue context
Post-translational modification studies for mapping phosphorylation, glycosylation, acetylation, and other regulatory events in situ
Comparative tissue analysis for evaluating molecular differences between disease and normal samples
Developmental and regenerative biology for understanding how protein expression changes across spatially defined tissue regions

Why Choose Us

Comprehensive service portfolio covering discovery, targeted analysis, multiplex imaging, and PTM mapping
Tailored project design based on your research question, sample characteristics, and target scope
Strong spatial biology expertise for interpreting protein expression within true tissue context
Advanced data analysis and visualization for clear interpretation of complex spatial proteomics datasets
End-to-end workflow management from consultation and sample assessment to data generation and final reporting
Commitment to scientific rigor through optimized workflows, robust QC, and careful result interpretation

FAQs

What types of samples can be used?

Spatial proteomics is commonly performed on tissue sections, including fresh frozen and FFPE samples, depending on the platform and study objectives. Sample suitability may vary by method, so project evaluation is recommended before study initiation.

Can I combine spatial proteomics with other multi-omics data?

Yes. Our bioinformatics team can integrate your spatial proteomics data with other datasets, such as spatial transcriptomics or bulk RNA-seq, to provide a multi-layered, holistic view of your tissue biology.

What is the typical turnaround time for a project?

Turnaround times vary based on the project size, complexity, and chosen technology. Generally, standard projects are completed within 3 to 4 weeks after we receive your samples. We will provide a specific timeline during the consultation phase.

Learn about other Q&A.

* For Research Use Only. Not for use in diagnostic procedures.

Our customer service representatives are available 24 hours a day, 7 days a week. Inquiry

From Our Clients

"I recently used their proteomics service for a project analyzing protein interactions in yeast models. The team was very responsive and helped clarify the methodology they employed, which made me feel confident in the results. The data quality was solid, with clear identification of several key proteins involved in our study. Their thorough analysis enabled me to pinpoint specific interactions that I hadn't considered before, which significantly improved the direction of my research. I appreciate their professionalism and support throughout the process."

Sarah Thompson, University of California, Berkeley

"Our lab collaborated with them on a project studying cancer biomarkers. The proteomics analysis provided was detailed and focused, specifically highlighting the differential expression of proteins between healthy and tumor samples. Their clear explanations of the data helped my team understand the biological implications. I also appreciated their willingness to revise the reports based on our feedback, ensuring that we had everything we needed for our publication. This collaborative spirit was invaluable."

Emily Rodriguez, Stanford University

"Our lab worked with them on a project studying the effects of diet on gut microbiota using proteomics. They used a label-free quantification method to analyze proteins in fecal samples before and after dietary intervention. The results showed significant changes in protein expression linked to microbial activity. This was pivotal for our hypothesis about diet-microbiota interactions. The clarity of their data presentation made it easy for our team to integrate these findings into our ongoing research."

Dr. Lisa Wong, University of Toronto

"My experience with Creative Proteomics during the mass spectrometry analysis was excellent. We sent in human saliva and mouse brain tissue samples, which they expertly analyzed using both LC-MS and GC-MS techniques. The results were invaluable, revealing key metabolites in the saliva and identifying biomarkers linked to brain function in the brain tissue."

Dr. Emily Carter, Senior Research Scientist

"The overall service from Creative Proteomics was outstanding. They made the entire process seamless and efficient, allowing us to focus on our research. We worked with leaf and root samples from various Arabidopsis genotypes for targeted metabolomics analysis. Their thorough profiling of primary and secondary metabolites gave us important insights into how the plants respond metabolically to environmental stress."

Dr. Laura Henderson, Plant Physiologist

"We had a pleasant collaboration with Creative Proteomics on mass spectrometry analysis of lipids. They conducted a detailed analysis of lipid species, providing us with important insights into lipid metabolism and its relationship with metabolic syndrome disease states."

Dr. Sarah Mitchell, Research Scientist

Online Inquiry

Please submit a detailed description of your project. We will provide you with a customized project plan to meet your research requests. You can also send emails directly to for inquiries.

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