Targeted Spatial Gene Expression Service

Our Targeted Spatial Gene Expression service delivers precise, high-resolution analysis of gene expression within the context of intact tissue using probe-based technology. Powered by state-of-the-art Xenium technology, we enable researchers to map the dynamic interplay between gene activity and tissue architecture. With the flexibility to target anywhere from a few hundred to several thousand genes, this service provides deep insights into cellular microenvironments and their critical roles in disease progression, therapeutic response, and biological development.

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Applications
Why choose
FAQs
Sample preparation

Workflow

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Applications

Immuno-Oncology Characterize the "immune desert" vs. "immune excluded" tumors; map checkpoint inhibitor expression relative to T-cell infiltration.
Neuroscience Map gene expression layers in the brain cortex; study localized inflammation in Alzheimer's plaques.
Developmental Biology Track cell differentiation trajectories within the developing embryo structure.
Pathology Identify molecular signatures in distinct histological regions (e.g., necrotic zones vs. viable tissue).

Why Choose Our Targeted Spatial Gene Expression Panels?

Comprehensive Spatial Insight: Gain a deeper understanding of how gene expression varies spatially across tissue sections, providing insights into complex biological systems that traditional transcriptomics methods cannot offer.
High Sensitivity and Specificity: By utilizing specific sets of targeted probes, the speed and accuracy of capturing low-abundance genes far exceed those of non-targeted methods.
Tailored Panels: We offer pre-designed panels for fields such as oncology, neuroscience, and immunology, while also supporting extensive customization.
Enhanced Resolution: Our platform delivers spatial resolution that allows you to examine the expression of genes at a cellular level, mapping gene activity within distinct regions of tissue.
End-to-End Delivery: We provide comprehensive, full-process delivery services—from sample processing, section preparation, and hybridization capture to advanced bioinformatics analysis.

FAQs

Can I customize the gene panel for my specific research?

Yes, our service is fully customizable. You can select from pre-designed gene panels or work with us to create a panel tailored to your specific research needs. Whether you need a small set of genes or a large panel for comprehensive analysis, we can accommodate your requirements.

What types of tissues are suitable for this analysis?

We can analyze a wide range of tissue types, including human and animal tissues, as well as organoids, biopsies, and more. The tissue must be either fresh frozen or properly fixed (FFPE) to maintain RNA integrity for accurate gene expression analysis.

Is there a minimum sample requirement for analysis?

Yes, there is a minimum tissue area requirement, typically 1-2 mm² of tissue per sample. The exact amount may vary based on the number of genes targeted in the panel, but we will ensure that your sample meets the minimum requirement to yield high-quality data.

Can I request a specific gene expression analysis in specific tissue regions?

Absolutely! The power of spatial transcriptomics is its ability to profile gene expression within distinct tissue regions. If you are interested in analyzing gene expression in a specific region, let us know, and we will adjust the experimental setup accordingly.

What is the typical turnaround time?

Our standard turnaround time is 3-4 weeks from sample receipt to final report delivery.

Learn about other Q&A.

Sample Requirements

For the Targeted Spatial Gene Expression Panels service, we require the following sample types:

Fresh Frozen Tissue: Tissue must be snap-frozen immediately after collection.
FFPE (Formalin-Fixed, Paraffin-Embedded) Tissue: Samples should be properly fixed and embedded in paraffin.

You can send the tissue blocks directly to our lab. We will handle all preparation steps, including sectioning, to ensure the best possible results for your analysis.

* For Research Use Only. Not for use in diagnostic procedures.

Our customer service representatives are available 24 hours a day, 7 days a week. Inquiry

From Our Clients

"I recently used their proteomics service for a project analyzing protein interactions in yeast models. The team was very responsive and helped clarify the methodology they employed, which made me feel confident in the results. The data quality was solid, with clear identification of several key proteins involved in our study. Their thorough analysis enabled me to pinpoint specific interactions that I hadn't considered before, which significantly improved the direction of my research. I appreciate their professionalism and support throughout the process."

Sarah Thompson, University of California, Berkeley

"Our lab collaborated with them on a project studying cancer biomarkers. The proteomics analysis provided was detailed and focused, specifically highlighting the differential expression of proteins between healthy and tumor samples. Their clear explanations of the data helped my team understand the biological implications. I also appreciated their willingness to revise the reports based on our feedback, ensuring that we had everything we needed for our publication. This collaborative spirit was invaluable."

Emily Rodriguez, Stanford University

"Our lab worked with them on a project studying the effects of diet on gut microbiota using proteomics. They used a label-free quantification method to analyze proteins in fecal samples before and after dietary intervention. The results showed significant changes in protein expression linked to microbial activity. This was pivotal for our hypothesis about diet-microbiota interactions. The clarity of their data presentation made it easy for our team to integrate these findings into our ongoing research."

Dr. Lisa Wong, University of Toronto

"My experience with Creative Proteomics during the mass spectrometry analysis was excellent. We sent in human saliva and mouse brain tissue samples, which they expertly analyzed using both LC-MS and GC-MS techniques. The results were invaluable, revealing key metabolites in the saliva and identifying biomarkers linked to brain function in the brain tissue."

Dr. Emily Carter, Senior Research Scientist

"The overall service from Creative Proteomics was outstanding. They made the entire process seamless and efficient, allowing us to focus on our research. We worked with leaf and root samples from various Arabidopsis genotypes for targeted metabolomics analysis. Their thorough profiling of primary and secondary metabolites gave us important insights into how the plants respond metabolically to environmental stress."

Dr. Laura Henderson, Plant Physiologist

"We had a pleasant collaboration with Creative Proteomics on mass spectrometry analysis of lipids. They conducted a detailed analysis of lipid species, providing us with important insights into lipid metabolism and its relationship with metabolic syndrome disease states."

Dr. Sarah Mitchell, Research Scientist

Online Inquiry

Please submit a detailed description of your project. We will provide you with a customized project plan to meet your research requests. You can also send emails directly to for inquiries.

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