Tissue & Cell Preparation Services

The foundation of any successful histological, pathological, or spatial omics study lies in the quality of the initial sample preparation. Our Tissue & Cell Preparation Services provide end-to-end, highly optimized solutions for preserving, processing, and sectioning biological specimens. Whether you are conducting routine morphological assessments, high-throughput biomarker screening, or advanced spatial omics, our state-of-the-art laboratory ensures your samples maintain optimal cellular integrity, antigenicity, and molecular preservation.

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overview of Digital & Molecular Pathology Service

Our services
Workflow
Platform
Applications
Why Choose
FAQs

Our Services

Service	Target Assays
Fresh Frozen Tissue Processing	single-cell RNA-Seq, spatial transcriptomics, spatial proteomics, spatial metabolomics
FFPE Tissue Processing	Immunohistochemistry (IHC), In Situ Hybridization (ISH), targeted DNA/RNA sequencing, long-term archiving.
Cryosectioning & Microtome	Routine staining (H&E), immunofluorescence (IF), spatial biology, slide scanning.
Serial & Large-Area Sectioning	3D tissue reconstruction, whole-organ assessment, neuroanatomy/brain mapping.
Histopathology Services	Morphological analysis, ROI (Region of Interest) Selection
Laser Capture Microdissection (LCM)	Cell-type-specific RNA/DNA sequencing, micro-proteomics, rare cell profiling.
Tissue Microarray (TMA) Preparation	High-throughput biomarker screening, large cohort validation, antibody optimization.
Multiplex Staining Optimization	Tumor microenvironment profiling, immune cell phenotyping, spatial proteomics.
Tissue Sectioning for Multi-Omics	Specialized, RNase-free sectioning for spatial transcriptomics and spatial proteomics platforms.

Workflow

Our streamlined process ensures transparency, speed, and strict quality control from start to finish:

Tissue & Cell Preparation Services workflow

Platform

Our laboratory is equipped with industry-leading, automated instrumentation to guarantee precision and reproducibility:

Advanced Microtomes & Cryostats: Motorized systems for ultra-consistent section thickness and minimal tissue vibration.
Automated Tissue Processors & Embedders: Ensuring uniform chemical infiltration and standardized block formation.
Laser Capture Systems: High-resolution microscopy integrated with precision infrared/UV lasers for accurate single-cell dissection.
Automated TMA Grand Masters: High-precision arrayers for flawless core extraction and recipient block insertion.
High-Resolution Slide Scanners: For brightfield and fluorescent whole-slide imaging and digital archiving.

Applications

Spatial Biology: Preparing tissues for downstream spatial omics analysis.
Multi-Modal Data Integration: Perfectly aligned serial sections enabling seamless integration of transcriptomic, proteomic, and morphological datasets from the exact same tissue region.

Why Choose Us

Strict Quality Control: Every project undergoes multi-point QC to ensure intact morphology and molecular viability.
Multi-Omics Ready: We utilize specialized protocols designed specifically to protect RNA and delicate epitopes for advanced spatial technologies.
Customization: We offer free one-on-one consultations and can provide customized services tailored to the specific requirements of your project.
Expert Team: Our professional experimental and bioinformatics analysis teams provide you with end-to-end services, ranging from experimentation to data interpretation.

FAQs

How should I prepare and ship my samples to your facility?

Shipping requirements depend entirely on the sample type. Fresh frozen tissues must be shipped overnight on dry ice to prevent thawing and degradation. FFPE blocks and unstained slides can typically be shipped at ambient temperature. We provide detailed, step-by-step shipping guidelines and manifests once your project is initiated.

Can you help me choose the right preparation method for my specific study?

Absolutely. We highly encourage a pre-project consultation. Our expert scientists will review your downstream research goals and recommend the most optimal fixation, embedding, and sectioning strategies to ensure success.

What happens if my sample fails the initial Quality Control (QC) check?

If a sample does not pass our incoming QC (for example, due to poor initial fixation, insufficient tissue volume, or severe degradation), we immediately pause the workflow and contact you. We will share the QC data and consult with you to decide whether to proceed with modifications, halt the processing, or wait for a replacement sample.

Learn about other Q&A.

* For Research Use Only. Not for use in diagnostic procedures.

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From Our Clients

"I recently used their proteomics service for a project analyzing protein interactions in yeast models. The team was very responsive and helped clarify the methodology they employed, which made me feel confident in the results. The data quality was solid, with clear identification of several key proteins involved in our study. Their thorough analysis enabled me to pinpoint specific interactions that I hadn't considered before, which significantly improved the direction of my research. I appreciate their professionalism and support throughout the process."

Sarah Thompson, University of California, Berkeley

"Our lab collaborated with them on a project studying cancer biomarkers. The proteomics analysis provided was detailed and focused, specifically highlighting the differential expression of proteins between healthy and tumor samples. Their clear explanations of the data helped my team understand the biological implications. I also appreciated their willingness to revise the reports based on our feedback, ensuring that we had everything we needed for our publication. This collaborative spirit was invaluable."

Emily Rodriguez, Stanford University

"Our lab worked with them on a project studying the effects of diet on gut microbiota using proteomics. They used a label-free quantification method to analyze proteins in fecal samples before and after dietary intervention. The results showed significant changes in protein expression linked to microbial activity. This was pivotal for our hypothesis about diet-microbiota interactions. The clarity of their data presentation made it easy for our team to integrate these findings into our ongoing research."

Dr. Lisa Wong, University of Toronto

"My experience with Creative Proteomics during the mass spectrometry analysis was excellent. We sent in human saliva and mouse brain tissue samples, which they expertly analyzed using both LC-MS and GC-MS techniques. The results were invaluable, revealing key metabolites in the saliva and identifying biomarkers linked to brain function in the brain tissue."

Dr. Emily Carter, Senior Research Scientist

"The overall service from Creative Proteomics was outstanding. They made the entire process seamless and efficient, allowing us to focus on our research. We worked with leaf and root samples from various Arabidopsis genotypes for targeted metabolomics analysis. Their thorough profiling of primary and secondary metabolites gave us important insights into how the plants respond metabolically to environmental stress."

Dr. Laura Henderson, Plant Physiologist

"We had a pleasant collaboration with Creative Proteomics on mass spectrometry analysis of lipids. They conducted a detailed analysis of lipid species, providing us with important insights into lipid metabolism and its relationship with metabolic syndrome disease states."

Dr. Sarah Mitchell, Research Scientist

Online Inquiry

Please submit a detailed description of your project. We will provide you with a customized project plan to meet your research requests. You can also send emails directly to for inquiries.

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