Spatial Metabolomics Service

Spatial metabolomics is a cutting-edge analytical approach that bridges the gap between traditional molecular analysis and histology. By combining advanced mass spectrometry imaging (MSI) with histological context, this technology allows researchers to map the precise spatial distribution and abundance of thousands of metabolites, lipids, and drugs directly within intact tissue sections. Without the need for complex labeling or staining, spatial metabolomics provides an unprecedented, multidimensional view of cellular metabolism, disease microenvironments, and drug interactions exactly where they occur in situ.

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overview of Digital & Molecular Pathology Service

Our services
Workflow
Platform
Applications
Why Choose
FAQs

Our Services

We offer a comprehensive suite of spatial metabolomics solutions tailored to meet the diverse needs of your research, from discovery phases to preclinical drug evaluation.

Core Profiling Services

Spatial Untargeted Metabolomics Service: Broad-spectrum mapping of endogenous metabolites and lipids to discover novel spatial biomarkers and understand global metabolic shifts.
Spatial Targeted Metabolomics Service: Highly sensitive, focused analysis of specific metabolic pathways or metabolite classes within tissue microenvironments.

Advanced Imaging Technologies

Quantitative Mass Spectrometry Imaging (qMSI) Service: Absolute quantification of target molecules across tissue sections using stable isotope-labeled standards.
MALDI Mass Spectrometry Imaging (MALDI-MSI) Service: High-spatial-resolution imaging utilizing Matrix-Assisted Laser Desorption/Ionization, ideal for a vast range of metabolites, lipids, and peptides.
DESI Mass Spectrometry Imaging (DESI-MSI) Service: Ambient ionization technique requiring minimal sample preparation, perfect for rapid lipidomic and small molecule mapping.
LA-ICP-MS Imaging Service: Laser Ablation Inductively Coupled Plasma Mass Spectrometry for high-resolution spatial mapping of trace elements and metals in tissues.

Pharmaceutical & Clinical Applications

Spatial Drug Distribution Analysis Service: Visualizing the precise localization and accumulation of drug compounds within target and off-target tissues.
In situ PK&PD Analysis Service: Correlating Pharmacokinetics with Pharmacodynamics directly within the spatial context of the tissue.
Drug Response & Spatial Pharmacology Studies: Evaluating how therapeutic interventions alter the metabolic landscape of a tissue over time.
Disease vs. Normal Comparative Spatial Metabolomics: Identifying region-specific metabolic alterations driving pathology by comparing diseased and healthy tissues.

Workflow

Our streamlined, end-to-end workflow ensures high-quality data and reproducible results for every project:

Spatial metabolomics Service workflow

Platform

Applications

Oncology: Mapping tumor heterogeneity, identifying invasive margins, and evaluating drug penetration in the tumor microenvironment.
Neuroscience: Visualizing lipidomic alterations in neurodegenerative diseases and mapping neurotransmitter distributions.
Drug Discovery & Development: Performing label-free tissue distribution studies (spatial ADME) and assessing localized drug toxicity.
Infectious Disease: Observing host-pathogen metabolic interactions directly at the site of infection.
Plant & Agricultural Sciences: Mapping agrochemicals, plant hormones, and secondary metabolites in roots, leaves, and seeds.

Why Choose Us

Comprehensive Technology Portfolio: We don't rely on a single technology; we match the right tool (MALDI, DESI, LA-ICP) to your specific biological question.
End-to-End Expertise: From delicate sample handling to complex spatial bioinformatics, our Ph.D.-level scientists manage every step.
Customized Solutions: We develop bespoke protocols for challenging tissue types or novel chemical entities.
High Resolution & Sensitivity: We leverage the latest instrumentation to push the boundaries of spatial and mass resolution.
Data Security & Quality Control: Rigorous QC checkpoints ensure reproducible, reliable, and secure data delivery.

FAQs

What types of samples can be analyzed?

We primarily analyze fresh-frozen tissue sections, as this preserves the native metabolic state best.

Do I need to label my drug or metabolite of interest?

No. Spatial metabolomics is a label-free technology. We detect molecules based on their exact mass-to-charge ratio (m/z).

What spatial resolution can be achieved?

Resolution depends on the chosen platform and the specific requirements of your study. We can achieve standard resolutions of 5–100 µm for routine tissue profiling.

How much tissue is required?

We typically require only a few tissue sections mounted on specialized conductive glass slides. We recommend providing a small block of tissue so we can optimize the sectioning and matrix application process.

Learn about other Q&A.

* For Research Use Only. Not for use in diagnostic procedures.

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From Our Clients

"I recently used their proteomics service for a project analyzing protein interactions in yeast models. The team was very responsive and helped clarify the methodology they employed, which made me feel confident in the results. The data quality was solid, with clear identification of several key proteins involved in our study. Their thorough analysis enabled me to pinpoint specific interactions that I hadn't considered before, which significantly improved the direction of my research. I appreciate their professionalism and support throughout the process."

Sarah Thompson, University of California, Berkeley

"Our lab collaborated with them on a project studying cancer biomarkers. The proteomics analysis provided was detailed and focused, specifically highlighting the differential expression of proteins between healthy and tumor samples. Their clear explanations of the data helped my team understand the biological implications. I also appreciated their willingness to revise the reports based on our feedback, ensuring that we had everything we needed for our publication. This collaborative spirit was invaluable."

Emily Rodriguez, Stanford University

"Our lab worked with them on a project studying the effects of diet on gut microbiota using proteomics. They used a label-free quantification method to analyze proteins in fecal samples before and after dietary intervention. The results showed significant changes in protein expression linked to microbial activity. This was pivotal for our hypothesis about diet-microbiota interactions. The clarity of their data presentation made it easy for our team to integrate these findings into our ongoing research."

Dr. Lisa Wong, University of Toronto

"My experience with Creative Proteomics during the mass spectrometry analysis was excellent. We sent in human saliva and mouse brain tissue samples, which they expertly analyzed using both LC-MS and GC-MS techniques. The results were invaluable, revealing key metabolites in the saliva and identifying biomarkers linked to brain function in the brain tissue."

Dr. Emily Carter, Senior Research Scientist

"The overall service from Creative Proteomics was outstanding. They made the entire process seamless and efficient, allowing us to focus on our research. We worked with leaf and root samples from various Arabidopsis genotypes for targeted metabolomics analysis. Their thorough profiling of primary and secondary metabolites gave us important insights into how the plants respond metabolically to environmental stress."

Dr. Laura Henderson, Plant Physiologist

"We had a pleasant collaboration with Creative Proteomics on mass spectrometry analysis of lipids. They conducted a detailed analysis of lipid species, providing us with important insights into lipid metabolism and its relationship with metabolic syndrome disease states."

Dr. Sarah Mitchell, Research Scientist

Online Inquiry

Please submit a detailed description of your project. We will provide you with a customized project plan to meet your research requests. You can also send emails directly to for inquiries.

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