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Metabolomics Service

Metabolomics refers to the systematic identification and quantification of the metabolome of a biological system at a specific point in time. And metabolome means the complete set of small-molecule chemicals found within a biological sample. In metabolomics, metabolites and their concentrations directly reflect underlying biochemical activity and state of cells or tissues. For metabolome profiling, mass spectrometry and NMR are the most commonly used techniques.

Metabolomics Service

Metabolomics Service at Creative Proteomics

At Creative Proteomics, we can provide a wide range of metabolomics services from discovery to targeted analysis.

ServicesDescription
Untargeted MetabolomicsIn untargeted metabolomics (also known as discovery metabolomics), all detectable metabolites of control and test groups are identified, quantitated, and compared to identify differences between their metabolite profiles. With integrated a set of separation, characterization, identification and quantification systems, Creative Proteomics provides reliable, rapid and cost-effective Untargeted Metabolomics.
Targeted MetabolomicsTargeted Metabolomics is a quantitative method for the identification and quantitative analysis of targeted metabolic compounds in organisms. We can provide a wide range targeted metabolomics services, including targeted metabolic pathways, targeted metabolites analysis, plant metabolites analysis, organic compounds analysis, etc.
Metabolic Flux Analysis (MFA)MFA, an experimental fluxomics, are widely used for examining production and consumption rates of metabolites in a biological system. Using stable isotopes and sensitive detection methods, we can provide MFA to determine pathway fluxes.
Unknown Metabolites IdentificationTo identify unknown metabolites, we have advanced instruments to provide accurate information like retention time, mass spectra, determination of the molecular mass and the elemental composition of the compound, etc. Combining this information with various algorithms, we can determine the identity of the compound.
Xenobiotic Metabolites AnalysisXenobiotics are foreign chemical compounds found within an organism, which is not naturally produced or expected to be present within the organism. Xenobiotic metabolites analysis is important for drug safety evaluation and wildlife refuge.
Untargeted LipidomicsLipidomics, a branch of metabolomics, is the large-scale study of pathways and networks of cellular lipids in biological systems. Untargeted lipidomics, based on mass spectrometry, can analyze hundreds and thousands of individual lipid species for unbiased qualitative and quantitative analysis of a lipidome.
Targeted LipidomicsTargeted lipidomics involves the identification and quantification of defined groups of known lipids across large sample sets. We can provide separation, characterization, identification and quantification for various types of lipids, including fatty acids, fatty acids derivatives, glycerolipids, glycerophosholipids, sphingolipids, sterols, and so on.
Exosome LipidomicsExosomes are small vesicles released from cells after fusion of the multivesicular bodies (MVBs) with the plasma membrane, which is reported to have the highest lipid-to-protein ratio of all classes of extracellular vesicles. Exosome lipidomics is a useful tool for lipid-based biomarkers and studies of vesicle biogenesis and function.
MALDI Imaging Lipidomics ServiceMALDI imaging mass spectrometry (MALDI-IMS), in which the ion source is matrix-assisted laser desorption ionization (MALDI) and a thin tissue section is moved in two dimensions while the mass spectrum is recorded, is useful to study the distribution of the lipids in tissues. Creative Proteomics provides a well-established solution of MALDI-Imaging.

Applications

Our metabolomics services can be applied to various fields, including but not limited to the agricultural industry, food industry, biomedical area, and pharmaceutical area.

  • Agricultural industry: plant metabolomics, the development of new pesticides, etc
  • Food industry: fruits, vegetables, dairy products, olive oil, etc
  • Biomedical area: metabolomic profiling, biomarker discovery, etc
  • Pharmaceutical area: drug toxicity, drug metabolism, etc

Our Advantages

  • The compounds we test are widely covered, ranging from small water-soluble molecules to large lipids.
  • We can analyze any biological materials, including but not limited to biofluids and tissues from animals, cell cultures and humans.
  • A comprehensive platform contains advanced instruments, including MS, GC-MS, LC-MS, NMR, and so on.
  • A complete analysis report is offered, including method interpretation, data, and result files.

Our experts with years of experience in metabolomics, bioinformatics, statistics and various application fields ranging from food to pharmacy can help you plan, conduct, and report your metabolomics studies. Whether you want to study the whole metabolome, complex lipids, or just a few metabolites or pathways, we will closely work with you to define research purpose and develop customized plans. If you have any questions or specific requirements, please don’t hesitate to contact us.

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