Plasmalogens Analysis Service


Plasmalogens  represent a class of phospholipids characterized by a vinyl ether bond in sn-1  and an ester bond in sn-2 position of the glycerol backbone. They are expressed  in numerous mammalian tissues at varying amounts and exhibit a distinct species  distribution. The predominant classes of plasmalogens are  glycerophosphoryl-ethanolamine (PE) and glycerophosphoryl-choline (PC),  depending on the head group.

The  basic chemical structure common to all plasmalogens is depicted in the above  figure. The long chain fatty alcohol (R1) in sn-1 consists almost exclusively  of 16:0, 18:0, and 18:1 alkenyl groups, while sn-2 (R2) is esterified  predominantly with ω-6 or ω-3 derived polyunsaturated fatty acids. While the  sn-2 acyl chain is at all segments oriented perpendicularly to the membrane  surface, the head group lacks a carbonyl oxygen in sn-1 position and therefore  exhibits a stronger lipophilicity. This change in headgroup structure in turn  leads to stronger intermolecular hydrogen bonding between head groups and is  able to directly disturb cellular membranes. Although plasmalogens constitute  18% of the total phospholipid mass in humans, for quite some time they have  been considered an oddity with no clearly ascribable physiological function  aside from being a membrane structure component.

Overview over  plasmalogen structure and biosynthesis  Figure 1 Overview over  plasmalogen structure and biosynthesis.

Till  now an increasing number of cellular functions have been uncovered, including  neurochemical effects, intra- and extra-cellular signaling, and the ability to  act as radical scavengers. There have also been reports on their involvement in  the proper assembly and function of multispan transmembrane transport proteins and ion-channels and on the diffusion of NO  and other signal-transduction molecules. Pathophysiologically they seem not  only to be involved in neurodegeneration, which was the first disease-association  discovered, but also play a role in common diseases such as cardiac failure,  type 2 diabetes, obesity, inflammation, and cancer. Further possibilities to  address plasmalogen biology in vivo were finally opened up in 2006 when an  ether-lipid deficient mouse model was generated.

Now,  scientists at Creative Proteomics have developed a reliable and reproducible  method using highly sensitive LC-MS/MS platform for the rapid identification  and quantification of diverse plasmalogens in different sample types. We’re  willing to provide Plasmalogens Analysis Service to satisfy the needs of  academic and industrial study in your lab.

Platform

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Sample Requirement

Report

Plasmalogens Quantified in This Service

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Staffed  by experienced biological scientists, Creative Proteomics can provide a wide range of services ranging from the  sample preparation to the lipid extraction, characterization, identification and quantification. We are willing to provide our customer the outstanding plasmalogens analysis service  with accurate and reliable results, quick turnaround,  saving you time and resources! Please feel free to contact us to  discuss the wide range of services we can perform.


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