Shikimic Acid Analysis Service


Shikimic Acid Analysis Service

Shikimic Acid is a cyclohexene, a cyclitol and a  cyclohexanecarboxylic acid and is more commonly known as shikimate, which is  the anionic form of Shikimic Acid. Shikimic Acid is an important biochemical intermediates and  products of metabolism in plants and microorganisms. Shikimic Acid was isolated by Johan Fredrik Eykman, a Dutch chemist  in 1885 from theapanese flower shikimiand its name is also comes from the  Japanese flower. The chemical structure of Shikimic  Acid was elucidated by by Hermann O. L. Fischer and German chemist Gerda  dangschat until 1934. Shikimic Acid mainly is isolated from the dried ripe fruit of Illiciaceae plants octagonal or  Illicium anisatum (Japanese star anise), and there are also have reported that Shikimic Acid can be extracted from the  sweetgum fruit and pine needles in recent years.

Scientists at Creative Proteomics utilize a highly quantitative method with  high-performance liquid chromatography (HPLC)  for the determination of Shikimic Acid levels in various samples, including  Plants, Fungi, Microbes and more. High-Performance Liquid Chromatography (HPLC) using a differential refractive  index detector (RID) for the determination of Shikimic Acid levels in a lot of  biological samples. This Methodology provides accurate, reliable, and  reproducible results of Shikimic Acid measurement, which enables us to analyze  of Shikimic Acid levels in vitro and in vivo.

Shikimic Acid from the Chinese star anise (Illicium verum) is is  used as a fundamental raw material for production of oseltamivir (Tamiflu),  which is a medication for the treatment of influenza A and B strains and has  been successfully developed and launched into the market in the pharmaceutical  industry. Shikimic Acid is a  biosynthetic intermediate and found in very low concentrations in generally  although it is present in most autotrophic organisms. There are some chemical  research papers reporting that Shikimic  Acid can be extracted in yields of around 1.5% from the seeds of the  sweetgum (Liquidambar styraciflua) fruit, which is abundant in North America.  For instance, Shikimic Acid extracted from 4 kg of sweetgum seeds is enough for fourteen packages of  Tamiflu. Biosynthetic pathways in E. coli have recently been improved to allow  the organism to accumulate enough material to be used commercially.

The Russian-Polish botanist M. Tswett is  generally recognized as the first person to establish the principles of  chromatography. In a paper he presented in 1906, Tswett described how he filled  a glass tube with chalk powder (CaCO3) and, by allowing an ether solution of  chlorophyll to flow through the chalk, separated the chlorophyll into layers of  different colors. He called this technique “chromatography”. Fundamentally,  chromatography is a technique used to separate the components contained in a  sample. High Performance Liquid  Chromatography (HPLC) is a method able to separate non-volatile, thermally  unstable, and polar components separate or in a mixture. HPLC is a type of chromatography that, because of its wide  application range and quantitative accuracy, is regarded as an indispensable  analytical technique, particularly in the field of organic chemistry. It is  also widely used as a preparation technique for the isolation and purification  of target components contained in mixtures.

Shikimic Acid Analysis Service at Creative Proteomics supports your research in Shikimic Acid Analysis. HPLC Based  Analysis Service Platform enable us at Creative  Proteomics offers you a state-of-the-art Analysis Service.

Sample Type
Plants, Fungi, Microbes and more

Method
High-Performance Liquid Chromatography (HPLC) using a differential refractive index detector (RID) for the  determination of Shikimic Acid levels in a lot of biological samples. This Methodology provides accurate,  reliable, and reproducible results of Shikimic Acid measurement, which enables us to analyze of Shikimic Acid levels in vitro and in vivo.

Send us your samples,  you will get all information that you need!


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