Neurotransmitters Analysis Service


Neurotransmitters

Neurotransmitters, also named  as chemical transmitter, are a great variety of chemical agents released  by neurons to stimulate neighbouring neurons. Through this way,  impulses to are transferred from one cell to the next throughout  the nervous system. The synapse is the site where neurons meet,  consisting of the axon terminal of one cell and  the dendrite of the next. A synaptic cleft is a microscopic gap  existing between the neurons. When arriving at the axon terminal of  one neuron, the nerve impulse would elicit the presynaptic membrane to release  a chemical substance. The release of the chemical substance is stimulated by  the electrical activity of the neuron. The chemical substance can be  transported at extremely high speed to the postsynaptic membrane of the  adjoining neuron. It will take only milliseconds for the chemical substance to  transfer across the synaptic cleft. The chemical substances like this are  called neurotransmitters. The identified neurotransmitters include dopamine,  norepinephrine, acetylcholine, and serotonin.

The precursors of neurotransmitters  are plentiful and simple such as amino acids and biogenic amines. These  precursors are readily available from the diet and only simple biosynthetic  steps are needed to convert the precursors to neurotransmitters. Though only  one kind of neurotransmitter are produced and released by some neurons, most  neurons make and release more than one neurotransmitter at any given time.  Because of the coexistence of more than one neurotransmitter in the synapse, it  is possible for the cell to exert several influences at the same time. In  the axon terminal on the presynaptic side of a synapse, there are some  synaptic vesicles clustered beneath the membrane. Neurotransmitters are packaged into these synaptic vesicles.  Though low-level baseline release of neurotransmitters occurs without  electrical stimulation, peak-level release of neurotransmitters usually is  stimulated by an action potential at the synapse or a graded electrical  potential.

In recent years, neurotransmitters have  been the subject of intensive investigations. For example, because of its  effect on alertness, memory and learning, an essential neurotransmitter in the  central nervous system, acetylcholine has been widely studied. Several issues  must be considered, when select a method for separation and quantification.  Since the concentration and the volume of most neurotransmitters in the extracellular  space is rather low, the developed analytical method should be able to work  with the smallest sample volume and provide detection limits lower than the  lowest concentration in the dialysate.

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Neurotransmitter Quantified in Our Service

With integrated set of separation,  characterization, identification and quantification systems featured with  excellent robustness & reproducibility, high and ultra-sensitivity,  Creative Proteomics provides reliable, rapid and cost-effective neurotransmitters targeted metabolomics  services.


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