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Amino Acids and Derivatives Analysis Service

Amino acids are organic compounds containing basic amino and acidic carboxyl groups, which are the basic units of enzymes and proteins. As small biological molecules, amino acids play an important role in physiological functions and clinical diagnosis. In general, amino acids play the following roles in the body: (1) synthesize tissue proteins; (2) turn into ammonia-containing substances such as acids, hormones, antibodies, and creatine; (3) transform into carbohydrates and fats; and (4) oxidize into carbon dioxide and water and urea to produce energy.

There are 20 common amino acids according to the structure on the side chain R group. According to nutritional classification, it is divided into essential amino acids, semi-essential amino acids and conditionally essential amino acids. In addition, there are nearly a hundred kinds of derivatives of amino acids. Different amino acids and their derivatives have different nutritional values and physiological functions, and play different roles in the body. If the body is deficient in any one amino acid, it may lead to abnormal physiological functions,affect the normal progress of metabolism and finally lead to diseases. Arginine and citrulline are important for urea formation; insufficient intake of cystine can cause decreased insulin and increased blood sugar, etc. The presence of amino acids not only provides important raw materials for protein synthesis, but also provides the material basis for promoting growth, carrying out normal metabolism and maintaining life. If one of them is missing, the normal metabolism of the organism will be impaired, even leading to the occurrence of various diseases or the termination of life activities.

Our Amino Acids and Derivatives Analysis Service

After years of technical accumulation, Creative Proteomics has combined GC/MS and LC/MS/MS to achieve quantitative and qualitative analysis of more than 100 amino acids and their derivatives, including 8 essential amino acids and 2 semi-essential amino acids and conditionally essential amino acids, 10 non-essential amino acids, and other amino acids.

Quantitative Amino Acids List
No	Metabolite	No	Metabolite	No	Metabolite	No	Metabolite
1	Glycine	30	L-Homoserine	59	Cysteinylglycine	88	N-Acetylaspartic acid
2	L-Alanine	31	L-Thyronine	60	Guanidoacetic acid	89	N-Acetylcysteine
3	L-Arginine	32	1-Methyl-L-histidine	61	Homocitrulline	90	N-Acetylglutamic acid
4	L-Asparagine	33	3-Methyl-L-histidine	62	Homoarginine	91	N-Acetylglutamine
5	L-Aspartic acid	34	2-aminobutyric acid	63	Argininosuccinic acid	92	N-Acetylhistidine
6	L-Cysteine	35	2-Aminoisobutyric acid	64	Glycylproline	93	N-Acetylisoleucine
7	L-Cystine	36	3-Aminobutyric acid	65	Glycyl-L-leucine	94	N-Acetylleucine
8	L-Glutamic acid	37	3-Aminoisobutyric acid	66	Carnosine	95	N-Acetylmethionine
9	L-Glutamine	38	Gamma-Aminobutyric acid	67	Anserine	96	N-Acetylphenylalanine
10	L-Histidine	39	2,3-Diaminopropionic acid	68	Cystathionine	97	N-Acetylproline
11	L-Isoleucine	40	2-Aminoadipic acid	69	Glycyl-glycine	98	N-Acetyltryptophan
12	L-Leucine	41	3-Chlorotyrosine	70	O-Acetylserine	99	N-Acetyltyrosine
13	L-Lysine	42	2-Phenylglycine	71	Phenylacetylglutamine	100	N-Acetylvaline
14	L-Methionine	43	3-Methylcrotonylglycine	72	Phenylacetylglycine	101	N-Acetyllysine
15	L-Ornithine	44	3-Nitrotyrosine	73	Phosphoserine	102	N-Acetylcitrulline
16	L-Phenylalanine	45	4-Acetamidobutyric acid	74	S-Adenosylhomocysteine	103	N6-Acetyllysine
17	L-Proline	46	4-Amino-3-hydroxybutyric acid	75	S-Adenosylmethionine	104	Ureidopropionic acid
18	L-Serine	47	4-Hydroxyphenylglycine	76	Sarcosine	105	Ureidosuccinic acid
19	L-Threonine	48	4-Hydroxyproline	77	S-Carboxymethylcysteine	106	Cinnamoylglycine
20	L-Tryptophan	49	5-Aminopentanoic acid	78	Methylcysteine	107	Formylglycine
21	L-Tyrosine	50	5-Hydroxytryptophan	79	gamma-Glutamylalanine	108	Isobutyrylglycine
22	L-Valine	51	5-Hydroxylysine	80	gamma-Glutamylglutamine	109	Isovalerylglycine
23	L-Norleucine	52	6-Aminocaproic acid	81	N-Acetylaspartylglutamic acid	110	N-Phenylacetylphenylalanine
24	L-Norvaline	53	Asymmetric dimethylarginine	82	Phenylalanylphenylalanine	111	Tiglylglycine
25	L-Pipecolic acid	54	Symmetric dimethylarginine	83	Dimethylglycine	112	Valylglycine
26	L-Kynurenine	55	Beta-Alanine	84	N-Acetylarginine	113	3-Iodo-L-tyrosine
27	L-Allo-isoleucine	56	Pyroglutamic acid	85	N2-Acetylornithine	114	3,5-Diiodo-L-tyrosine
28	L-Homocysteine	57	Citrulline	86	Acetylglycine	115	Thyroxine
29	L-Homocystine	58	Creatine	87	N-Acetylalanine

Amino Acids and Derivatives Analysis Workflow

Sample Requirements

Animal and clinical tissue samples: > 5-10mg

Blood samples (serum, plasma and whole blood):>10uL

Urine sample:>10uL

Fecal and intestinal contents:>10mg

Body fluid samples (cerebrospinal fluid and saliva, etc.): >5-10μL

Plant tissue samples (roots, stems, leaves flowers and fruits, etc.): >10mg

Cells and microorganisms:>1*10^5cells

Culture medium and fermentation broth:>10μL

Platform

Agilent UHPLC-MS/MS

Waters UPLC-AB Sciex MS/MS

Thermo Scientific Orbitrap MS

Agilent GC-MS

Applications

Phenome and physiological function studies.

Early clinical prediction, diagnosis and treatment studies.

Pathology studies.

Natural drugs and pharmacological research.

Food science, safety and nutrition research.

Livestock and agroforestry research.

Botanical and environmental research.

Toxicological research.

* For Research Use Only. Not for use in diagnostic procedures.

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