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Amino Acids and Derivatives Analysis Service Online Inquiry

Amino acids are organic compounds containing basic amino and acidic carboxyl groups, which are the basic units of enzymes and proteins. As small biological molecules, amino acids play an important role in physiological functions and clinical diagnosis. In general, amino acids play the following roles in the body: (1) synthesize tissue proteins; (2) turn into ammonia-containing substances such as acids, hormones, antibodies, and creatine; (3) transform into carbohydrates and fats; and (4) oxidize into carbon dioxide and water and urea to produce energy.

There are 20 common amino acids according to the structure on the side chain R group. According to nutritional classification, it is divided into essential amino acids, semi-essential amino acids and conditionally essential amino acids. In addition, there are nearly a hundred kinds of derivatives of amino acids. Different amino acids and their derivatives have different nutritional values and physiological functions, and play different roles in the body. If the body is deficient in any one amino acid, it may lead to abnormal physiological functions,affect the normal progress of metabolism and finally lead to diseases. Arginine and citrulline are important for urea formation; insufficient intake of cystine can cause decreased insulin and increased blood sugar, etc. The presence of amino acids not only provides important raw materials for protein synthesis, but also provides the material basis for promoting growth, carrying out normal metabolism and maintaining life. If one of them is missing, the normal metabolism of the organism will be impaired, even leading to the occurrence of various diseases or the termination of life activities.

Our Amino Acids and Derivatives Analysis Service

After years of technical accumulation, Creative Proteomics has combined GC/MS and LC/MS/MS to achieve quantitative and qualitative analysis of more than 100 amino acids and their derivatives, including 8 essential amino acids and 2 semi-essential amino acids and conditionally essential amino acids, 10 non-essential amino acids, and other amino acids.

Quantitative Amino Acids List
NoMetaboliteNoMetaboliteNoMetaboliteNoMetabolite
1Glycine30L-Homoserine59Creatine88N-Acetylalanine
2L-Alanine31L-Thyronine60Cysteinylglycine89N-Acetylaspartic acid
3L-Arginine321-Methyl-L-histidine61Guanidoacetic acid90N-Acetylcysteine
4L-Asparagine333-Methyl-L-histidine62Homocitrulline91N-Acetylglutamic acid
5L-Aspartic acid342-aminobutyric acid63Homoarginine92N-Acetylglutamine
6L-Cysteine352-Aminoisobutyric acid64Argininosuccinic acid93N-Acetylhistidine
7L-Cystine363-Aminobutyric acid65Glycylproline94N-Acetylisoleucine
8L-Glutamic acid373-Aminoisobutyric acid66Glycyl-L-leucine95N-Acetylleucine
9L-Glutamine38Gamma-Aminobutyric acid67Carnosine96N-Acetylmethionine
10L-Histidine392,3-Diaminopropionic acid68Anserine97N-Acetylphenylalanine
11L-Isoleucine402-Aminoadipic acid69Cystathionine98N-Acetylproline
12L-Leucine413-Chlorotyrosine70Glycyl-glycine99N-Acetyltryptophan
13L-Lysine422-Phenylglycine71O-Acetylserine100N-Acetyltyrosine
14L-Methionine433-Methylcrotonylglycine72Phenylacetylglutamine101N-Acetylvaline
15L-Ornithine443-Nitrotyrosine73Phenylacetylglycine102N-Acetyllysine
16L-Phenylalanine454-Acetamidobutyric acid74Phosphoserine103N-Acetylcitrulline
17L-Proline464-Amino-3-hydroxybutyric acid75S-Adenosylhomocysteine104N6-Acetyllysine
18L-Serine474-Hydroxyphenylglycine76S-Adenosylmethionine105Ureidopropionic acid
19L-Threonine484-Hydroxyproline77Sarcosine106Ureidosuccinic acid
20L-Tryptophan495-Aminolevulinic acid78S-Carboxymethylcysteine107Cinnamoylglycine
21L-Tyrosine505-Aminopentanoic acid79Methylcysteine108Formylglycine
22L-Valine515-Hydroxytryptophan80gamma-Glutamylalanine109Isobutyrylglycine
23L-Norleucine525-Hydroxylysine81gamma-Glutamylglutamine110Isovalerylglycine
24L-Norvaline536-Aminocaproic acid82N-Acetylaspartylglutamic acid111N-Phenylacetylphenylalanine
25L-Pipecolic acid54Asymmetric dimethylarginine83Phenylalanylphenylalanine112Tiglylglycine
26L-Kynurenine55Symmetric dimethylarginine84Dimethylglycine113Valylglycine
27L-Allo-isoleucine56Beta-Alanine85N-Acetylarginine1143-Iodo-L-tyrosine
28L-Homocysteine57Pyroglutamic acid86N2-Acetylornithine1153,5-Diiodo-L-tyrosine
29L-Homocystine58Citrulline87Acetylglycine116Thyroxine

Amino Acids and Derivatives Analysis Workflow

Amino Acids and Derivatives Analysis Workflow

Sample Requirements

Animal and clinical tissue samples: > 5-10mg

Blood samples (serum, plasma and whole blood):>10uL

Urine sample:>10uL

Fecal and intestinal contents:>10mg

Body fluid samples (cerebrospinal fluid and saliva, etc.): >5-10μL

Plant tissue samples (roots, stems, leaves flowers and fruits, etc.): >10mg

Cells and microorganisms:>1*10^5cells

Culture medium and fermentation broth:>10μL

Platform

Agilent UHPLC-MS/MS

Waters UPLC-AB Sciex MS/MS

Thermo Scientific Orbitrap MS

Agilent GC-MS

Applications

Phenome and physiological function studies.

Early clinical prediction, diagnosis and treatment studies.

Pathology studies.

Natural drugs and pharmacological research.

Food science, safety and nutrition research.

Livestock and agroforestry research.

Botanical and environmental research.

Toxicological research.

* For Research Use Only. Not for use in diagnostic procedures.
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