Fumaric Acid Analysis Service


Fumaric Acid Analysis Service

Fumaric Acid is also known as trans-butenedioic acid and is white  crystalline chemical compound with the formula HO2CCH=CHCO2H. Fumaric Acid is one of two isomeric  unsaturated dicarboxylic acids and the other is maleic acid, which is a less  stable molecule than Fumaric Acid. Fumaric Acid can be found in fumitory,  bolete mushrooms, especially in Boletus fomentarius other than  pseudo-igniarius, lichen, and Iceland moss.

Scientists at Creative Proteomics utilize a highly quantitative method with  high-performance liquid chromatography (HPLC)  for the determination of Fumaric Acid levels in various samples, including Food  and more. High-Performance Liquid Chromatography (HPLC) with UV detection is used for the determination of Fumaric  Acid (213 nm) levels in a lot of biological samples. This Methodology provides  accurate, reliable, and reproducible results of Fumaric Acid measurement, which  enables us to analyze of Fumaric Acid levels in vitro and in vivo.

Fumarate acid is an intermediate in the citric acid  cycle, which is is a series of chemical reactions used by all aerobic organisms  to generate energy y in the form of adenosine triphosphate (ATP). Fumarate acid  is formed by the oxidation form succinate by the enzyme succinate  dehydrogenase, which is an enzyme complex bound to the inner mitochondrial  membrane of mammalian mitochondria, in the following biochemical reactions,  fumarate acid is converted to malate catalyzing by the enzyme named fumarase.  Fumarate is also a product of the urea cycle, which is a cycle of biochemical  reactions occurring in many animals that produces urea ((NH2)2CO) from ammonia  (NH3). Fumaric Acid has been  approved for use as a food additive in the Eu, USA and Australia and New  Zealand. The results from clinical phase 3 trial of Biogen show that dimethyl  fumarate, which is is the methyl ester of Fumaric  Acid can significantly reduce relapse and disability progression in  patients with relapsing-remitting multiple sclerosis.

The Russian-Polish botanist M. Tswett is  generally recognized as the first person to establish the principles of  chromatography. In a paper he presented in 1906, Tswett described how he filled  a glass tube with chalk powder (CaCO3) and, by allowing an ether solution of  chlorophyll to flow through the chalk, separated the chlorophyll into layers of  different colors. He called this technique “chromatography”. Fundamentally,  chromatography is a technique used to separate the components contained in a  sample. High Performance Liquid  Chromatography (HPLC) is a method able to separate non-volatile, thermally  unstable, and polar components separate or in a mixture. HPLC is a type of chromatography that, because of its wide  application range and quantitative accuracy, is regarded as an indispensable  analytical technique, particularly in the field of organic chemistry. It is  also widely used as a preparation technique for the isolation and purification  of target components contained in mixtures.

Fumaric Acid Analysis Service at Creative Proteomics supports your research in Fumaric Acid Analysis. HPLC Based Analysis Service Platform enable us at Creative Proteomics offers you a state-of-the-art Analysis Service.

Sample Type
Food and more

Method
High-Performance Liquid Chromatography (HPLC) with UV detection is used for the determination of Fumaric Acid (213 nm) levels in a lot  of biological samples. This Methodology provides accurate, reliable, and  reproducible results of Fumaric Acid measurement, which enables us to analyze of Fumaric Acid levels in vitro and in vivo.

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