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Home > Services > Metabolomics Service > Targeted Metabolomics > Organic Acids Analysis Service

Organic Acids Analysis Service

Organic Acids Analysis Service

Organic acids are defined as organic compounds with acidic properties. Because these acids are organic, their structure must contain a carbon atom. Carboxylic acid, with the molecular formula as RCOOH, is one of the most common organic acids. Sulfonic acid and alcohol are also organic acids. Generally speaking, organic acids are weak acids, which can only partially ionize in solution. Organic acids are widely used in food industry. For example, citric acid is widely used in sodas and canned tomatoes and acetic acid is well known organic acid used for making vinegar. Organic acids are also as additives in pharmaceutical production, leather tanning.

Organic acids are the result of incomplete oxidation of photosynthetic assimilates. They can go through terminal oxidation and yield CO2 and H2O. Their carbon skeletons can also be used for the raw materials of biosynthesis of carbohydrates or amino acids. Because organic acids are the intermediate products of complete oxidation, they paly an important role in redox balance maintenance, generation and consumption of ATP, and sustaining protonic and ionic gradients on membranes.

Organic acids play a vital role in the primary metabolism of plant. They are involved in the essential physiological pathways such as TAC cycle, glyoxylate cycle, and C3-, C4- and CAM-photosynthesis. Organic acids can be converted to each other in many plant tissues and they can also be the degradation products of more reduced compounds. Organic acids like lactate, fumarate, malate, and citrate, takes part in many vital cellular processes, pH regulation, stomatal function, aluminum tolerance, phosphorous acquisition, temporary carbon storage and communication with microorganisms. Besides regulating the primary and specialized metabolic pathways, organic acids also involve with the regulation of the development and growth of plant. For example, they act as signaling molecules, as modulators for many key enzymes or as regulators of gene expression.

Organic acids widely exist in foods and beverages, and partially or totally contribute to the taste and aroma of the product. Organic acids can not only being generated in foods spontaneously, but also produced during food processing such as alcoholic fermentation. The profiling as well as their quantification of organic acids in fruits, cheeses, and various beverages assists in determining the quality and authenticity of the product.

Platform

  • GC-MS

Summary

  • Identification & Quantification of Organic Acids

Sample Requirement

  • Normal Volume: 200uL plasma, 100 mg tissue, (2E7) cells
  • Minimal Volume: 100uL plasma, 50 mg tissue, (5E6) cells

Report

  • A detailed technical report will be provided at the end of the whole project, including the experiment procedure, MS instrument parameters.
  • Analytes are reported as uM/ml, while CV's are generally 10%.
  • The name of the analytes, abbreviation, formula, molecular weight and CAS# would also be included in the report.

Organic Acids Quantified in Our Service

Organic Acids Quantified in Our Service
1 Organic Acid
2 (E)-Cinnamic acid
3 1H-Indole-3-acetic acid
4 2-amino-benzoic acid
5 2-Furoylglycine
6 2-Hydroxy-2-methylbutyric acid
7 2-Hydroxybenzoic acid (salicylic acid)
8 2-Hydroxyglutaric acid
9 2-Hydroxyisovaleric Acid
10 2-Indolecarboxylic acid
11 2-Methylsuccinic acid
12 3,4-dihydroxy-Phenylpropanoic acid
13 3,4-Dihydroxyphenylacetic acid
14 3-(3-Hydroxyphenyl) propanoic acid
15 3-Hydroxybutyric acid
16 3-Hydroxyisovaleric acid
17 3-Hydroxymethylglutaric acid
18 3-Methyladipic acid
19 3-Methylglutaconic acid
20 4-Deoxythreonate
21 4-Hydroxyhippuric acid
22 5-Hydroxyindoleacetic acid
23 Adipic acid
24 alpha-Hydroxylsobutyric acid
25 Azelaic acid
26 Benzenepropanoic acid
27 Benzoic acid
28 beta-Lactate
29 Citric acid
30 Dodecadioic acid (Lauric acid)
31 Ethylmalonic acid
32 Fumaric acid
33 Glutaconic acid
34 Glutaric acid
35 Hexadecanoic acid (Palmitic acid)
36 Hippuric acid
37 Homovanillic acid
38 HPHPA
39 Hydroxyphenyllactic acid
40 Indolelactic acid
41 Kynurenic acid
42 L-Malic acid
43 Lactic acid
44 Levulinic acid
45 m-Coumaric acid
46 m-Hydroxyhippuric acid
47 m-Hydroxyphenylacetic acid
48 Malonic acid
49 Methylmaleic acid (citraconic acid)
50 Methylmalonic acid
51 o-Hydroxyphenylacetic acid
52 Octadecanoic acid (Stearic acid)
53 Oxoglutaric acid
54 p-Hydroxybenzoic acid
55 p-Hydroxyphenylacetic acid
56 Phenaceturic acid
57 Phenylacetic acid
58 Pimelic acid
59 Pyroglutamic acid
60 Pyruvic acid
61 Quinolinic acid
62 Sebacic acid
63 Suberic acid
64 Succinic acid
65 Sumiki's acid
66 Trans-Aconitic acid
67 Trans-Ferulic acid
68 Vanillylmandelic acid
69 2-hydroxybutyric acid
70 2-hydroxy-3-methylvaleric acid
71 5-hydroxyhexanoic acid
72 Mevalonolactone
73 2,4-dihydroxybutanoic acid
74 2-methylmalic acid
75 3-phenyllactic acid
76 2-hydroxyadipic acid
77 4-hydroxymandelic Acid

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With integrated set of separation, characterization, identification and quantification systems featured with excellent robustness & reproducibility, high and ultra-sensitivity, Creative Proteomics provides reliable, rapid and cost-effective organic acids targeted metabolomics services.


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