Polyols Analysis Service
At Creative Proteomics, we offer precise polyol analysis services to detect, identify, and quantify polyols in food, pharmaceuticals, cosmetics, and environmental samples. Our advanced LC-MS and HPLC techniques ensure high sensitivity, accuracy, and quick turnaround times, helping businesses ensure product quality, regulatory compliance, and consistency while identifying impurities and optimizing formulations.
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- What We Provide
- List of Polyols
- Technology Platform
- Advantages
- Sample Requirements
- Demo
- FAQs
- Publications
What are Polyols?
Polyols are a diverse group of organic compounds that contain multiple hydroxyl groups (-OH) attached to a carbon chain. These compounds are typically produced through the reduction of sugars, converting aldehyde or ketone groups into alcohol groups. Polyols are often used as sugar substitutes because they have a sweet taste but are lower in calories compared to traditional sugars. Additionally, polyols have various industrial applications due to their ability to act as moisture stabilizers, emulsifiers, and texture enhancers.
Polyols can be naturally occurring or synthetically produced, depending on their intended use. Their safety and regulatory approval depend on their chemical structure and the context of their use, making accurate analysis essential in ensuring product quality and consumer safety.
What We Can Offer?
At Creative Proteomics, we provide a comprehensive range of polyol analysis services designed to meet the needs of various industries. Our services are geared toward accurately detecting, identifying, and quantifying polyols in complex samples.
Quantification of Polyols in Food and Beverages
- Ensure compliance with industry regulations for sugar substitutes.
- Accurate quantification of polyols to maintain product consistency.
Purity Testing and Quality Control
- Assess the purity and consistency of polyols in raw materials, intermediates, and final products.
- Detection of potential impurities or contaminants in polyol-based formulations.
Polyol Characterization and Identification
- Characterization of polyol structures using advanced analytical techniques.
- Structural elucidation of new polyols or polyol derivatives in development.
Environmental and Wastewater Analysis
- Detection of polyols in environmental samples to ensure safe discharge levels.
- Monitoring polyol contamination in industrial effluents.
Pharmaceutical and Cosmetic Applications
- Testing for polyols in pharmaceutical excipients, active ingredients, and cosmetic formulations.
- Ensuring the stability, safety, and quality of polyol-containing products.
List of Polyols We Can Analyze
| Polyol Name | Common Uses | Chemical Formula | Notes |
|---|---|---|---|
| Sorbitol | Sweetener, humectant, food, and pharmaceutical products | C₆H₁₄O₆ | Widely used in sugar-free products, pharmaceuticals |
| Mannitol | Diuretic, sweetener, food and pharmaceutical excipient | C₆H₁₄O₆ | Common in sugar-free food and as a drug excipient |
| Xylitol | Sweetener, oral care products | C₅H₁₂O₅ | Popular in sugar-free gum and dental products |
| Erythritol | Low-calorie sweetener, food and beverage applications | C₄H₁₀O₄ | Naturally occurring and used in various food products |
| Maltitol | Sweetener, food, and pharmaceutical applications | C₁₂H₂₆O₁₁ | Used in sugar-free products and as a humectant |
| Isomalt | Sweetener, confectionery products | C₁₂H₂₄O₁₁ | Sugar substitute in candies and confectionery |
| Lactitol | Sweetener, pharmaceutical excipient | C₁₂H₂₆O₁₁ | Used in pharmaceutical formulations and as a laxative |
| Trehalose | Sugar substitute, stabilizer in pharmaceuticals and food | C₁₂H₂₂O₁₁ | A natural disaccharide, used in cosmetics and foods |
| Arabitol | Food and beverage, sugar alcohol | C₅H₁₂O₅ | Less commonly used, but useful in various food products |
| Ribitol | Intermediate in the biosynthesis of vitamins and sugars | C₅H₁₂O₅ | Can be found in natural sources such as fruits |
| Erythritol-2-phosphate | Research purposes, enzyme substrates | C₄H₁₀O₅P | Used in biochemistry and metabolic studies |
| Glucitol | Sweetener, food, and pharmaceutical excipient | C₆H₁₄O₆ | Another name for sorbitol, widely used in food and drugs |
| Pentaerythritol | Crosslinking agent in coatings, paints, and plastics | C₅H₁₂O₄ | Used in the production of alkyd resins and as a stabilizer |
| Mannose | Used in food, immunology studies | C₆H₁₂O₆ | Monosaccharide with applications in health research |
| Fucose | Important in glycosylation and cell signaling | C₆H₁₂O₆ | Important in glycobiology studies and immunology |
| Inositol | Used in cosmetics, pharmaceuticals | C₆H₁₂O₆ | Often used in cell signaling and metabolic studies |
| Sorbitan | Emulsifier in cosmetics and pharmaceuticals | C₆H₁₄O₆ | Often used as emulsifiers in cosmetic formulations |
| Xylitol-5-phosphate | Research applications in metabolic pathways | C₅H₁₂O₆P | Used in enzymatic and metabolic studies |
| D-glucitol (Glucitol) | Industrial and pharmaceutical use | C₆H₁₄O₆ | Used in various industrial applications, including cosmetics |
Methods for Polyol Detection
For polyol detection, we primarily use LC-MS (Liquid Chromatography-Mass Spectrometry) and HPLC (High-Performance Liquid Chromatography). LC-MS offers high sensitivity for identifying and quantifying polyols in complex samples, providing both structural confirmation and accurate mass measurement. HPLC is used for separating and quantifying polyols, especially in food, pharmaceutical, and cosmetic formulations, with detection typically using refractive index (RI) or evaporative light scattering detectors (ELSD). These techniques ensure precise and reliable analysis.
Agilent 1260 Infinity II (Figure from Agilent)
SCIEX Triple Quad 6500+ System (Figure from SCIEX)
Agilent 7890B GC-MS (Figure from Agilent)
Advantages of Our Polyol Assay
- High Sensitivity and Accuracy: Our LC-MS and HPLC systems offer detection limits as low as 0.1 ng/mL for polyols, ensuring highly sensitive quantification and identification in complex matrices.
- Fast Turnaround Time: We provide results within 2-4 weeks, even for high-complexity samples, allowing for quick decision-making in product development and quality control.
- Comprehensive Identification: Our advanced techniques can accurately identify a wide range of polyols, including isomers and derivatives, with an accuracy rate of over 98% for mass spectral matching.
- Tailored Analysis: We offer customizable testing protocols to suit specific requirements, whether you need routine analysis or complex, novel polyol investigations, ensuring flexibility for various industries.
- Reliable Reporting: Our detailed reports include precise polyol concentrations, structural information, and impurity profiles, providing all the data needed for quality control, research, or regulatory submissions.
Sample Requirements for Polyols Analysis
| Sample Type | Minimum Quantity | Storage Conditions | Preparation Guidelines | Remarks |
|---|---|---|---|---|
| Solid Samples | 10 mg | Store at room temperature (if stable), or refrigerate (if needed) | Homogenize the sample to ensure uniformity. | Please ensure samples are dry and free from contaminants. |
| Liquid Samples | 1 mL | Refrigerate at 4°C until analysis | If viscous, dilute with an appropriate solvent. | Ensure sample is well-mixed before submission. |
| Food/Beverage Samples | 10-20 g (solid) or 5-10 mL (liquid) | Store according to product type (e.g., refrigeration for perishable goods) | For liquids, centrifuge if particulate matter is present. | Provide ingredient information to help identify polyols. |
| Pharmaceutical Samples | 5-10 mg (solid) or 1-2 mL (liquid) | Store as per product's packaging guidelines | If in tablet form, crush to powder for accurate analysis. | Include product formulation details for accurate identification. |
| Environmental Samples | 50 mL (liquid) or 10 g (solid) | Keep refrigerated or frozen until submission | For liquid samples, filter before submitting; solid samples should be representative of the sample area. | Ensure no cross-contamination occurs. |
| Cosmetic Samples | 5-10 g | Store at room temperature or as specified on the product label | Homogenize or dissolve the sample for consistent analysis. | Provide product composition for better analysis. |
| Wastewater Samples | 50 mL | Refrigerate at 4°C until analysis | If large sample volume, please send in sealed containers to avoid degradation. | Include any processing details relevant to polyol content. |
Applications of Polyols
Food and Beverage Industry
Polyols are frequently used as sweeteners in sugar-free and reduced-calorie products. Our analysis ensures that polyols meet regulatory and safety standards.
Pharmaceuticals
Polyols are used in excipients and drug formulations. We provide analysis to ensure the stability and quality of polyol-containing drugs.
Cosmetics
Polyols are used in moisturizers and skin care products. Our services help identify any impurities or contaminants.
Environmental Testing
Polyols are increasingly used in various industrial processes. We monitor their presence in wastewater and environmental samples to ensure compliance with environmental regulations.
Demo Result of Targeted Metabolomics Service
Figures come from (Li, Y.et.al, Sci Rep,2023)
Quickly show the distribution of samples across principal components.
OPLS-DA point cloud diagram
Illustrate the separation of sample groups in a multidimensional space.
Plot of multiplicative change volcanoes
Volcano plot depicting multiplicative changes in metabolite levels.
Sample Hierarchical Clustering
Each column in the figure represents a sample
FAQ of Polyols Analysis
What specific sample collection methods should I use for polyol analysis?
For solid samples, it's crucial to ensure that the sample is representative of the entire batch. This means taking a composite sample from multiple points to avoid variability. For liquid samples, ensure that the sample is well-mixed, as polyols can sometimes settle or separate. If you are collecting from food or beverage products, we recommend collecting the sample directly from the batch or container you wish to analyze, using clean, contaminant-free tools.
How do you handle samples that contain a high amount of interfering substances?
In samples with high levels of interfering substances, such as fats, proteins, or salts in food and pharmaceutical formulations, we use optimized sample preparation protocols. This can include solid-phase extraction (SPE), filtration, or centrifugation to remove the matrix components that could affect the polyol quantification. Additionally, advanced mass spectrometry techniques like multiple reaction monitoring (MRM) are employed to enhance sensitivity and minimize interference.
What if my sample is too small for standard analysis?
If your sample quantity is below the required minimum, we can still proceed with the analysis by using concentrated extraction methods or increasing the detection sensitivity. We may also suggest sample enrichment or multiplexing techniques to compensate for small sample volumes. For certain complex matrices, we also offer customized extraction protocols that are optimized for limited quantities.
Can polyol analysis be used to confirm the purity of my polyol product?
Yes, polyol purity analysis is one of the primary applications of our service. Using LC-MS or HPLC, we can accurately quantify your polyol content and identify the presence of any impurities or degradation products. This is especially important if you are manufacturing or formulating polyols and need to ensure that the product meets purity standards. The report will highlight any deviations from expected purity levels.
How do I know if my polyol concentration is within the desired range?
We provide customized reference ranges based on your specific needs. If you're looking to achieve a particular polyol concentration in your formulation, we can help determine whether the levels fall within your acceptable range. If concentrations are too high or low, we offer insights into potential causes (e.g., degradation or improper synthesis) and suggest steps for improvement. We also provide you with precise, quantitative results down to the microgram level.
Can you perform polyol analysis on mixtures or complex formulations?
Yes, our techniques are highly effective for analyzing polyol mixtures or complex formulations. Using chromatographic separation followed by mass spectrometry, we can isolate and identify multiple polyols in a single sample. If your formulation contains different polyols or polyol derivatives, we can differentiate them based on their mass spectra and chromatographic behavior, even when they are present in trace amounts.
What should I do if I suspect my polyol sample has been compromised or degraded during transport?
If you believe your sample has been compromised, it is important to notify us immediately so that we can assess the sample condition upon arrival. We will evaluate the sample integrity based on appearance and any signs of degradation, such as color change or separation. If needed, we will implement protective measures during the analysis, such as shortening storage periods or employing fresh sample reprocessing, to ensure the results are as accurate as possible.
How are polyol analysis results validated, and can you confirm the presence of specific polyol structures?
Our results are validated through rigorous internal controls and replicate analysis to ensure consistency. We also perform comparative analysis against known standards for polyol identification. For structural confirmation, we use MS/MS fragmentation patterns and retention time comparisons to verify polyol structures. If you are testing a specific compound or derivative, we can tailor the analysis to confirm its presence by targeting its unique molecular signature in the chromatographic and mass spectra data.
Learn about other Q&A.
Polyols Analysis Case Study
Publications
Here are some publications in proteomics research from our clients:
- Polyamine metabolism impacts T cell dysfunction in the oral mucosa of people living with HIV. 2023. https://doi.org/10.1038/s41467-023-36163-2
- Methyl donor supplementation reduces phospho‐Tau, Fyn and demethylated protein phosphatase 2A levels and mitigates learning and motor deficits in a mouse model of tauopathy. 2023. https://doi.org/10.1111/nan.12931
- Comparative metabolite profiling of salt sensitive Oryza sativa and the halophytic wild rice Oryza coarctata under salt stress. 2024. https://doi.org/10.1002/pei3.10155
- Elevated SLC7A2 expression is associated with an abnormal neuroinflammatory response and nitrosative stress in Huntington’s disease. 2024. https://doi.org/10.1186/s12974-024-03038-2
- Sarcosine Is Uniquely Modulated by Aging and Dietary Restriction in Rodents and Humans. 2018. https://doi.org/10.1016/j.celrep.2018.09.065
