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Phenolic Acids Analysis Service

Phenolic acids, also known as phenolcarboxylic acids, are types of aromatic acid compound. They are also a subclass of a larger category of metabolites commonly referred to as “phenolics”. The term phenolics consists of approximately 8000 naturally occurring compounds, all of which have one common structural feature, a phenol (an aromatic ring bearing at least one hydroxyl substituent). The broad category of phenolics can be divided into polyphenols and simple phenols, based merely on the number of phenol subunits present. Polyphenols containing at least two phenol substituent groups encompass the flavonoids, and such compounds containing three or more phenol substituent groups are known as the tannins (hydrolyzable and non-hydrolyz-able). Two important naturally occurring types of phenolic acids are hydroxycinnamic acids and hydroxybenzoic acids, which are derived from non-phenolic molecules of benzoic and cinnamic acid, respectively.

Distribution for phenolic acids in living organisms Figure 1 Distribution for phenolic acids in living organisms.

Phenolic acids can be found in a number of plant species. Their content in dried fruits can be very high. Natural phenols in horse grams are typically phenolic acids, that is 3,4-dihydroxy benzoic, caffeic, vanillic, p-coumaric, sinapinic and syringic acids. Multiple phenolic acids can be found in human urine. Phenolic acids can also be found in mushroom. It is a part of the humic substances, which are the main organic constituents of soil humus.

The name “phenolic acids” typically describes phenols that possess one carboxylic acid functional group. Nevertheless, when describing plant metabolites, it refers to a different group of organic acids. These naturally occurring phenolic acids possess two distinguishing constitutive carbon frameworks: the hydroxycinnamic and hydroxybenzoic structures. Although the main skeleton remains the same, the positions and numbers of the hydroxyl groups on the aromatic ring produce the variety. In a lot of cases, aldehyde analogues are grouped in with, and known as, phenolic acids. P-coumaric, caffeic, ferulic, vanillic, and protocatechuic are acids present in nearly all plant species.

Currently, a reliable and reproducible method using highly sensitive LC-MS/MS platform for the rapid identification and quantification of diverse phenolic acids in different sample types has been developed by the experienced biological scientists at Creative Proteomics, which can meet the needs of academic and industrial study in your lab.


  • LC-MS/MS


  • Identification and quantification of diverse phenolic acids by targeted metabolomics

Sample Requirement

  • Normal Volume: 100ul plasma; 50mg tissue; 2e7 cells
  • Minimal Volume: 50uL plasma; 30mg tissue; 5e6 cells


  • A full report including all raw data, MS/MS instrument parameters and step-by-step calculations will be provided (Excel and PDF formats).
  • Analytes are reported as uM or ug/mg (tissue), and CV's are generally<10%.
Phenolic Acids
Caffeic acidFerulic acidOther phenolic acids
P-coumaric acidProtocatechuic acidVanillic acid

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Staffed by experienced biological scientists, Creative Proteomics can provide a wide range of services ranging from the sample preparation to the lipid extraction, characterization, identification and quantification. We are willing to provide our customer the outstanding phenolic acids analysis service with accurate and reliable results, quick turnaround, saving you time and resources! Please feel free to contact us to discuss the wide range of services we can perform.

* For Research Use Only. Not for use in diagnostic procedures.
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