Tryptamine Analysis Service


Tryptamine Analysis Service

Tryptamine is a kind of monoamine alkaloid, which contains an  indole ring structure, and the structure is similar to the amino acid  tryptophan. Tryptamine is reported  in trace amounts in the brains of mammals, and the concentration of Tryptamine in rat brains is about 3.5  pmol/g. The function of is Tryptamine in brain is hypothesized to play a role as a neuromodulator or  neurotransmitter. Tryptamine is one  of common functional group in a set of compounds termed substituted Tryptamines collectively, which  includes many biologically activecompounds, for example neurotransmitters and  psychedelic drugs.

Scientists at Creative  Proteomics utilize a highly quantitative method with high-performance  liquid chromatography (HPLC) for the  determination of Tryptamine levels in various samples, including Serum, Tissue  and more. Biogenic amines of Tryptamine in a lot of biological samples were  detected by High-Performance Liquid Chromatography (HPLC), using precolumn derivatization with DNS-Cl. This Methodology  provides accurate, reliable, and reproducible results of Tryptamine  measurement, which enables us to analyze of Tryptamine levels in vitro and in  vivo.

Small amounts of Tryptamine is also can be found in Many plants, and it is a feedstock for the metabolic  pathways which influence plant growth and microbiome.For example, it is  reported can be as a possible intermediate in in one biosynthetic pathway for  one of plant hormone- indole-3-acetic acid. Higher concentrations can be found in many Acacia species. In vertebrates, Tryptamine acts as a non-selective  serotonin receptor agonist and serotonin-norepinephrine-dopamine releasing  agent (SNDRA), which has a preference for evoking serotonin and dopamine  release over norepinephrine release. Tryptamine has a very short half-life in vivo because it is rapidly metabolized by MAO-A  and MAO-B. Tryptamine also is  reported as a noncompetitive inhibitor for serotonin N-acetyltransferase  (SNAT), which catalyzes the anabolic metabolism of serotonin into  N-acetylserotonin, neuromodulator and the immediate precursor for melatonin in  mosquitoes.

The Russian-Polish botanist M. Tswett is  generally recognized as the first person to establish the principles of  chromatography. In a paper he presented in 1906, Tswett described how he filled  a glass tube with chalk powder (CaCO3) and, by allowing an ether solution of  chlorophyll to flow through the chalk, separated the chlorophyll into layers of  different colors. He called this technique “chromatography”. Fundamentally,  chromatography is a technique used to separate the components contained in a  sample. High Performance Liquid  Chromatography (HPLC) is a method able to separate non-volatile, thermally  unstable, and polar components separate or in a mixture. HPLC is a type of chromatography that, because of its wide  application range and quantitative accuracy, is regarded as an indispensable  analytical technique, particularly in the field of organic chemistry. It is  also widely used as a preparation technique for the isolation and purification  of target components contained in mixtures.

Tryptamine Analysis  Service at Creative Proteomics supports your research in Tryptamine Analysis. HPLC Based Analysis Service Platform enable us at Creative Proteomics offers you a state-of-the-art Analysis Service.

Sample  Type
Serum, Tissue and more

Method
Biogenic  amines of Tryptamine in a lot of  biological samples were detected by High-Performance Liquid Chromatography (HPLC), using precolumn derivatization  with DNS-Cl. This Methodology provides accurate, reliable, and reproducible  results of Tryptamine measurement,  which enables us to analyze of Tryptamine levels in vitro and in vivo.

Send us your samples, you will get all information that you  need!


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