Cadaverine is also known by the names 1,5-pentanediamine and pentamethylenediamin and is a foul-smelling diamine compound because it is produced by protein hydrolysis during the process of animal tissue putrefaction.Cadaverine is a toxic diamine, and is first reported by Ludwig Brieger , who is a Berlin physician in 1885. Cadaverine is the decarboxylation product of the amino acid lysine, and the chemical formulation is NH2(CH2)5NH, which is similar to putrescine.
Scientists at Creative Proteomics utilize a highly quantitative method with high-performance liquid chromatography (HPLC) for the determination of Cadaverine levels in various samples, including Serum, Tissue and more. Biogenic amines of Cadaverine in a lot of biological samples were detected by High-Performance Liquid Chromatography (HPLC), using precolumn derivatization with DNS-Cl. This Methodology provides accurate, reliable, and reproducible results of Cadaverine measurement, which enables us to analyze of Cadaverine levels in vitro and in vivo.
Cadaverine is produced by the decarboxylation of the amino acid lysine, which contains a ε-amino group (NH3+) attached to the fifth carbon. Cadaverine is poisonous and irritating to the skin and is harmful if Cadaverine is ingested, inhaled, or absorbed through the skin. Cadaverine is very destructive of mucous membranes and can cause burns. Cadaverine has a low oral toxicity in the rats experiment. Cadaverine can cause a decrease in blood pressure after intravenous administration in rats in a dose dependent manner. The decreased body weights associated with diminished food intake is observed when the diet of the rats contains high dose of Cadaverine. The level of Cadaverine is higher than normal level in some patients with lysine metabolism deficiency. Cadaverine is also used as a chemical intermediate to produce of high polymers in some biological research.
The Russian-Polish botanist M. Tswett is generally recognized as the first person to establish the principles of chromatography. In a paper he presented in 1906, Tswett described how he filled a glass tube with chalk powder (CaCO3) and, by allowing an ether solution of chlorophyll to flow through the chalk, separated the chlorophyll into layers of different colors. He called this technique “chromatography”. Fundamentally, chromatography is a technique used to separate the components contained in a sample. High Performance Liquid Chromatography (HPLC) is a method able to separate non-volatile, thermally unstable, and polar components separate or in a mixture. HPLC is a type of chromatography that, because of its wide application range and quantitative accuracy, is regarded as an indispensable analytical technique, particularly in the field of organic chemistry. It is also widely used as a preparation technique for the isolation and purification of target components contained in mixtures.
Cadaverine Analysis Service at Creative Proteomics supports your research in Cadaverine Analysis. HPLC Based Analysis Service Platform enable us at Creative Proteomics offers you a state-of-the-art Analysis Service.
Serum, Tissue and more
Biogenic amines of Cadaverine in a lot of biological samples were detected by High-Performance Liquid Chromatography (HPLC), using precolumn derivatization with DNS-Cl. This Methodology provides accurate, reliable, and reproducible results of Cadaverine measurement, which enables us to analyze of Cadaverine levels in vitro and in vivo.
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