Low Molecular Weight Sugars Analysis Service

Low Molecular Weight Sugars

Carbohydrates are the most abundant  and diverse components of many foods such as cereals, vegetables, fruits,  potatoes, and flour. Chemically they are composed of carbon, hydrogen, and  oxygen and symbolized with the chemical formula (CH2O)n. Carbohydrates can  exist as individual molecules or physically associated or chemically attached  to other molecules. According to the number of monomers, individual  carbohydrate molecules can be classified as monosaccharides, oligosaccharides  or polysaccharides. When carbohydrate molecules covalently attached to  proteins, the proteins are regarded as glycoproteins. When carbohydrate  molecules covalently attached to lipids, the lipids are known as glycolipids.  Some carbohydrates are digestible and act as crucial energy source for humans  while other carbohydrates are indigestible and fail to act as energy source.  Carbohydrates that can be digested, such as lignin, are regarded as dietary  fiber. It is shown that consumption of sufficient quantities of dietary fiber  is of great benefits of human nutrition and health, reducing the risk of  diabetes and constipation, coronary heart disease and certain types of cancers.  Besides acting as an important source of energy and dietary fiber, carbohydrates  also contribute to the appearance, textural and sweetness of many  foods.

Monosaccharide, most often known  simple sugar or low molecular weight sugar, is water-soluble crystalline  compounds with the simplest form of carbohydrate. They are aliphatic aldehydes or ketones with  one or more hydroxyl groups and one carbonyl group as reactive centers. Commonly occurring hexoses in foods are glucose, fructose  and galactose, whilst commonly occurring pentose like arabinose and xylose  are the most abundant monosaccharide in food. Other monosaccharide in food  included glucose, fructose and galactose, which act as energy source for  organisms. Monosaccharides are also building blocks for more complex  carbohydrates and other macromolecules important for organisms. For example, ribose and deoxyribose are monosaccharides are the building blocks of RNA and  DNA, two important genetic macromolecules crucial for life. What’s more, derivatives of monosaccharides also play important roles. For example, vitamin  C is a monosaccharide derivative serving as an important antioxidant.

For a number of reasons, it is of  great importance to determine the concentration and type of carbohydrates in  food. A large number of analytical platforms have been developed to detect the  type of and the total concentration carbohydrates in foods. Creative Proteomics  has developed a robust, reproducible and highly sensitive LC-MS/MS method using  a multiple-reaction monitoring (MRM) mode for the simultaneous quantification  of monosaccharides derived from glycoprotein and blood serum. Reduction, derivatization  or postcolumn addition of reagents is not necessary. This method exhibit very  high sensitivity to carbohydrates with limits of detection of 1 pg and with linearity  ranging over three orders of magnitude (pg to ng).



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Low Molecular Weight Sugars Quantified in This Service

With integrated set of separation, characterization, identification and quantification systems featured with  excellent robustness & reproducibility, high and ultra-sensitivity, Creative Proteomics provides reliable, rapid and cost-effective low molecular weight sugars targeted metabolomics services.

* For Research Use Only. Not for use in diagnostic procedures.
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