Straight chain fatty acids are the basic building block in the universe of lipids. They are composed of a carboxylic acid with a long and unbranched chain of carbon atoms. The number of carbons in the fatty acid varies among species. In higher organisms like mammals, fatty acids always consist of an even number of carbons, however in lower organisms like bacteria, odd number of carbon also exists. Most naturally occurring fatty acids have 4 to 26 carbons, but longer fatty acids of up to 35 carbons are also described in literature.
According to the number of carbons, Straight chain fatty acids can be classified into short chain fatty acids (SCFA, C2–C7), medium chain fatty acids (MCFA, C8–C13), long chain fatty acids (LCFA, C14–C19), and very long chain fatty acids (VLCFA, C20+). Straight chain fatty acids are either saturated or unsaturated with one or more double bonds.
Figure 1. Straight chain fatty acids: hexadecanoic acid
In cells, straight chain fatty acids play important biological roles. They have a variety functions, including being incorporated into membrane for membrane proliferation, energy storage, generation of signaling molecules, or oxidized to carbon dioxide as energy source. The levels of straight chain fatty acids are sensitive to metabolic perturbations, therefore, they can be served as good markers for many health conditions and diseases. So far, the profiling of straight chain fatty acid has lead to the discovery of many disease markers, including insulin resistance, type 2 diabetes, obesity, cardiovascular diseases, cancers, and many other diseases.
Creative Proteomics offers a comprehensive profiling of straight chain fatty acids that satisfy a variety of purposes. GC/MS platform enables more sensitive and selective assay of fatty acid measurement. GC/MS techniques serves as a powerful analytical tool for identification and quantification of fatty acids.
Features and advantages of straight chain fatty acid analysis
- Cutting-edge facilities
- Reliable & Reproducible
- Comprehensive analysis of straight chain fatty acids
Platform
- GC/MS
Sample Requirement
- Normal Volume: 200ul plasma; 100mg tissue; 2e7 cells
- Minimal Volume: 50uL plasma; 50mg tissue; 5e6 cells
| Straight Chain Fatty Acids Quantified in This Service | |
|---|---|
| Arachidic acid | (C20:0) |
| Arachidonic acid | (C20:4n6) |
| Butyric acid | (C4:0) |
| Behenic acid | (C22:0) |
| Capric acid | (C10:0) |
| Caproic acid | (C6:0) |
| Caprylic acid | (C8:0) |
| cis-10-Heptadecenoic acid | (C17:1) |
| cis-10-Pentadecenoic acid | (C15:1) |
| cis-11,14,17-Eicosatrienoic acid | (C20:3n3) |
| cis-11,14-Eicosadienoic acid | (C20:2) |
| cis-11-Eicosenoic acid | (C20:1) |
| cis-13,16-Docosadienoic acid | (C22:2) |
| cis-4,7,10,13,16,19-Docosahexaenoic acid | (C22:6n3) |
| cis-5,8,11,14,17-Eicosapentaenoic acid | (C20:5n3) |
| cis-8,11,14-Eicosatrienoic acid | (C20:3n6) |
| Elaidic acid | (C18:1n9t) |
| Erucic acid | (C22:1n9) |
| g-Linolenic acid | (C18:3n6) |
| Heneicosanoic acid | (C21:0) |
| Heptadecanoic acid | (C17:0) |
| Lauric acid | (C12:0) |
| Lignoceric acid | (C24:0) |
| Linoleic acid | (C18:2n6c) |
| Linolelaidic acid | (C18:2n6t) |
| Linolenic acid | (C18:3n3) |
| Myristic acid | (C14:0) |
| Myristoleic acid | (C14:1) |
| Nervonic acid | (C24:1) |
| Oleic acid | (C18:1n9c) |
| Palmitic acid | (C16:0) |
| Palmitoleic acid | (C16:1) |
| Pentadecanoic acid | (C15:0) |
| Stearic acid | (C18:0) |
| Tricosanoic acid | (C23:0) |
| Tridecanoic acid | (C13:0) |
| Undecanoic acid | (C11:0) |
For other species in straight chain fatty acid family, please contact us for availability.
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