Straight chain fatty acids are the basic building block in the universe of lipids. They are composed of a carboxylic acid with a long and unbranched chain of carbon atoms. The number of carbons in the fatty acid varies among species. In higher organisms like mammals, fatty acids always consist of an even number of carbons, however in lower organisms like bacteria, odd number of carbon also exists. Most naturally occurring fatty acids have 4 to 26 carbons, but longer fatty acids of up to 35 carbons are also described in literature.
According to the number of carbons, Straight chain fatty acids can be classified into short chain fatty acids (SCFA, C2–C7), medium chain fatty acids (MCFA, C8–C13), long chain fatty acids (LCFA, C14–C19), and very long chain fatty acids (VLCFA, C20+). Straight chain fatty acids are either saturated or unsaturated with one or more double bonds.
Figure 1. Straight chain fatty acids: hexadecanoic acid
In cells, straight chain fatty acids play important biological roles. They have a variety functions, including being incorporated into membrane for membrane proliferation, energy storage, generation of signaling molecules, or oxidized to carbon dioxide as energy source. The levels of straight chain fatty acids are sensitive to metabolic perturbations, therefore, they can be served as good markers for many health conditions and diseases. So far, the profiling of straight chain fatty acid has lead to the discovery of many disease markers, including insulin resistance, type 2 diabetes, obesity, cardiovascular diseases, cancers, and many other diseases.
Creative Proteomics offers a comprehensive profiling of straight chain fatty acids that satisfy a variety of purposes. GC/MS platform enables more sensitive and selective assay of fatty acid measurement. GC/MS techniques serves as a powerful analytical tool for identification and quantification of fatty acids.
Features and advantages of straight chain fatty acid analysis
Straight Chain Fatty Acids Quantified in This Service
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