Sphingomyelin Profiling Service


Sphingomyelin profiling service provides data  on all individual molecular species. Sphingomyelins (SM) constitute an  important class of phospholipids in the membranes of most eukaryotic cells. In  mammalian tissues, SM usually constitute 2–15% of the total organ phospholipid,  but certain tissues such as brain, peripheral nervous tissue and ocular lenses  have even higher SM contents, especially in some nerve  cell axons. Sphingomyelin  (or ceramide phosphorylcholine) consists of a  ceramide unit  with a phosphorylcholine moiety attached. Sphingomyelin does not appear to  occur in plants or fungi, which produce ceramide phosphorylinositol instead, or  in bacteria with rare exceptions, and its evolutionary significance is a matter  for speculation.

Sphingomyelin Profiling Service

Sphingomyelin profiling  service provides data on all individual molecular species. We recommend these  profiling scans at the semi-quantitative level, which allows direct comparison  between samples or treatments. Sphingomyelin  usually isolated from animal tissues by TLC or HPLC. The peaks or bands usually  split into two or three resolved fractions, due to the changes in  hydrophobicity resulting from the wide range of chain lengths in the fatty acid  constituents, or to the presence of 2-hydroxy acids. Molecular species of the  intact lipid can be resolved by reversed-phase HPLC, but another useful  approach is to hydrolyse to the less polar ceramides with the enzyme  phospholipase C, analysed the ceramides instead. Sphingomyelin profiling service at Creative Proteomics ESI Liquid Chromatography Mass Spectrometry (ESI- LC/MS) is  used for the analysis of sphingomyelin and other sphingo-phospholipids.

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Sphingomyelin Profile Panel

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With integrated set of  separation, characterization, identification and quantification systems  featured with excellent robustness & reproducibility, high and  ultra-sensitivity, Creative Proteomics provides reliable, rapid and  cost-effective Lipidomics services.


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