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Structure-based Evolution Analysis of Proteins Service

The extent of divergence in the three-dimensional (3D) structures of homologous proteins in a family is connected with the extent of similarity in these amino acid sequences. It is common knowledge that the 3D structures and structural features of homologous proteins are more conserved than their amino acid sequences. It has been demonstrated many times that the homologous proteins could diverge beyond recognition at the level of their amino acid sequences but maintain similar structure and function. While the relation between sequence divergence and structural divergence in homologous proteins indicate a gross exponential decrease of structural divergence as sequence similarity increases, this relation does not exist at low sequence similarities (below 30%). In some cases of low sequence similarity proteins preserve the fold as well as preserve the broad biochemical features and functional properties, indicating an evolutionary connection. Therefore, structure-based method is a useful way to study protein evolution. Several studies based on the known 3D structures of proteins show that two homologous proteins with insignificant sequence similarity could present a common fold and may perform similar or same biochemical functions. Now, bioinformaticians at Creative Proteomics are proud to tell you we are open to help you with Structure-based Evolution Analysis of Proteins Service!

Structure-based Evolution Analysis of Proteins Service

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As one of the leading omics industry company in the world! Creative Proteomics now is opening to provide structure-based evolution analysis of proteins service for our customers. With over 8 years experience in the field of bioinformatics, we are willing to provide our customer the most outstanding service! Contact us for all the detailed information!


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