Sphingosine-1-phosphate (S1P) is a signaling sphingolipid, and it is the product of phosphorylation of sphingosine by sphingosine kinase. S1P can be dephosphorylated to sphingosine by sphingosine phosphatases and can be irreversibly degraded by an enzyme, sphingosine phosphate lyase. Many cells secrete S1P, which can then affect other cells in an autocrine or paracrine manner.
Sphingosine-1-phosphate has been shown to have a wide range of biological roles. Sphingosine-1-phosphate has been shown to enhance cell growth and inhibit the normal apoptotic response. Numerous studies have shown that production of S1P promotes tumor growth, resistance to apoptosis, tumor angiogenesis and metastasis. S1P was also shown to promote angiogenesis. It also increases intracellular calcium levels by promoting the release of calcium from internal stores. Moreover, Sphingosine-1-phosphate has been shown to regulate the production of pro-inflammatory cytokines, Toll-like receptor signaling and inflammation, which links to diabetes, obesity, and metabolic syndrome.
Figure 1. Structure of Sphingosine-1-phosphate
The advantages of LC-MS/MS method include relatively higher sensitivity and selectivity and short run times. With experienced scientists at Creative Proteomics, we have developed a reliable and reproducible method using highly sensitive LC-MS/MS method for the rapid identification and quantification of S1P in different sample types, which can satisfy the needs of academic and industrial study in your lab.
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