EuKaryotic Orthologous Groups, or KOGs, is a eukaryote-specific version of the Clusters of Orthologous Groups (COGs) for the identification of ortholog and paralog proteins. KOGs database include proteins from 7 eukaryotic genomes: three animals (Homo sapiens, the fruit fly Drosophila melanogaster and the nematode Caenorhabditis elegans), one plant, Arabidopsis thaliana, two fungi (Schizosaccharomyces pombe and Saccharomyces cerevisiae), and the intracellular microsporidian parasite Encephalitozoon cuniculi. The current KOG database consists of 4852 clusters of orthologs, which include 59,838 proteins, or ~54% of the eukaryotic 110,655 gene products. Now, Scientists at Creative Proteomics are very willing to offer our customers the best KOG Annotation Analysis Service.
KOGs provides four functional groups, each of which is subdivided into KOG classifications determined by letters of the alphabet. Within each classification, groups of orthologous or paralogous proteins are assigned a KOG ID. In contrast with the coverage of the prokaryotic genomes with COGs, a significantly smaller fraction of eukaryotic genes could be classified into the KOGs; addition of novel eukaryotic genomes is expected to result in marked increase in the coverage of eukaryotic genomes with KOGs. Examination of the phyletic patterns of KOGs reveals a conserved core existed in all analyzed species and accounting for ~20% of the KOG set. This conserved portion of the KOG set is much greater than the ever-present portion of the COG set (~1% of the COGs). To some extent, this difference is probably due to the small number of involved eukaryotic genomes, but it could also reveals the relative compactness of eukaryotes as a clade and the great evolutionary stability of eukaryotic genomes.
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As one of the leading omics industry company in the world! Creative Proteomics now is opening to provide KEGG annotation analysis service for our customers. With over 8 years experience in the field of bioinformatics, we are willing to provide our customer the most outstanding service! Contact us for all the detailed informations!
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