Sphingolipids are fundamental structural components of cell membranes. They also incorporate other components to form membrane lipid rafts. Sphingolipids are involved in the regulation of biological processes including cell growth, differentiation and apoptosis. Ceramide is the central hub of sphingolipids pathway, which includes sphingomyelins, gluco- and galactosylceramides, grouped as hexosylceramides (HexCer), lactosylceramides (LacCer), sphingosine(Sph), dihydrosphingosine (DhSph) and dihydroceramides (DhCer) among other compounds.
Figure 1. N-hexadecanoyl hexosylceramide
The level of HexCer changes at different physiological, pathological and disease conditions. It has been shown that hexosylceramide levels changes in brain aging. Moreover, it has been suggested that hexosylceramide-derived sphingolipids increased in the CSF of patients with multiple sclerosis. Recently, plasma hexosylceramide were also found to be significantly regulated in chronic hepatitis C, which make them good biomarkers for the disease.
The advantages of LC-MS/MS method include relatively higher sensitivity and selectivity and short run times. With experienced scientists at Creative Proteomics, we have developed a reliable and reproducible method using highly sensitive LC-MS/MS method for the rapid identification and quantification of hexosylceramide in different sample types, which can satisfy the needs of academic and industrial study in your lab.
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Metabolites Quantified in This Service
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