In biology, conserved sequences refers to similar or identical sequences that occur within nucleic acid sequences, protein sequences or polymeric carbohydrates across species or within different molecules produced by the same organism. In terms of cross species conservation, it indicates that a particular sequence may have been unchanged by evolution. The further back up the phylogenetic tree a specific conserved sequence may occur the more highly conserved it is said to be. Because sequence information is regularly transmitted from parents to offspring by genes, a conserved sequence indicates that there is a conserved gene. It is universally believed that mutation in a highly conserved region results in a non-viable life form, or a form that is eliminated by natural selection. What determines conserved and non-conserved depends on the environment. Now, bioinformaticians at Creative Proteomics are glad to tell you we are open to help you with Conserved Sequences Analysis Service!
Conserved sequences play important biological roles in cellular processes, including:
- Highly conserved sequences are usually required for basic cellular stability, function and reproduction. Sequence similarity is applied as evidence of structural conservation, functional conservation, and evolutionary relationships between sequences. As a result, functional elements are often identified by searching for conserved sequence in an entire genome.
- Conservation of protein-coding sequences results in the presence of identical amino acid residues at analogous domains of the protein structure with similar function. Conservative mutations just alter amino acids to similar chemically amino acid residues and so may still have no effect on the protein's function.
- Conserved non-coding sequences often harbor cis-regulatory elements. A number of deletions of highly conserved sequences in humans and other organisms have been suggested to be a latent cause of the anatomical and behavioral differences between humans and other mammals. The TATA promoter sequence is a typical example of a highly conserved DNA sequence found in most eukaryotes.
Applications of conserved sequences
- Aid medical research
- Assess risk of disease
- Understand the evolutionary history of distinct species
- Compare various alleles and their relationships with risk for a particular diseases or ailments
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As one of the leading omics industry company in the world! Creative Proteomics now is opening to provide conserved sequences analysis service for our customers. We hope you will find that we can meet your research needs. Contact us for all the detailed information!