At Creative Proteomics, our commitment lies in empowering pioneering research by providing unparalleled expertise in peptidomics and proteolysis targeting chimera (PROTAC) research. With a customer-centric focus, we tailor our methodologies to meet the specific needs of every project, ensuring the delivery of precise, actionable insights and facilitating advancements in proteolysis targeting chimera research.
PROTAC Research Based on Peptidomics
Proteolysis targeting chimeras (PROTACs) are small molecules formulated to discerningly degrade target proteins within cellular frameworks. They encompass two fundamental constituents: a ligand that recognizes the desired target protein and a ligand that binds to an E3 ubiquitin ligase. The E3 ligase actively recruits the target protein to the intracellular degradation apparatus, thereby instigating its disintegration through the proteasome. PROTACs have exhibited promising efficacy in the selective degradation of diverse disease-associated protein targets, including oncogenic proteins and resistant variants.
Key Focus:
- Target Identification and Validation
Our in-depth analyses provide invaluable insights into protein degradation pathways and aid in the rational design of tailored PROTAC molecules, driving target specificity and efficacy.
- Characterization of Protein-Protein Interactions
By unraveling these interactions, we empower researchers to strategically engineer PROTAC molecules that harness specific protein-protein associations, expanding the scope of targeted protein degradation efforts.
- Biomarker Discovery
Leveraging peptidomics, we facilitate the discovery and validation of peptide-based biomarkers associated with disease states, therapeutic responses, and cellular signaling pathways.
- Mechanistic Insights and Pathway Mapping
Peptidomic analyses offer unprecedented mechanistic insights, enabling our researchers to map intricate signaling pathways, post-translational modifications, and regulatory mechanisms.
Our Techniques and Instrumentation
- Liquid chromatography-mass spectrometry (LC-MS): The sample can be separated and sent to a mass spectrometer for analysis, and is often used for identification and quantitative analysis.
- Agilent 6460 Triple Quadrupole LC/MS System
- Thermo Fisher Scientific Q Exactive Plus LC-MS/MS System
- Waters Xevo TQ-S Micro Triple Quadrupole LC/MS System
- Shimadzu LCMS-8050 Triple Quadrupole LC/MS System
- Ion Mobility Lane (LIT): We are used to identify and quantify large molecules such as proteins and peptides with high sensitivity and high resolution.
- Waters SYNAPT G2-Si
- Bruker timsTOF Pro
- SCIEX SelexION
- Electrospray ionization (ESI): It is a common sample ionization technology, often used in conjunction with mass spectrometry, to convert molecules in the sample into charged ions so that they can enter the mass spectrometer.
- Constant targeted ion transport (SRM): It is a mass spectrometry analysis technology that selectively monitors specific target substances and is often used in the study of proteins and peptides.
Our Advantages
- State-of-the-art instrumentation: We utilize advanced mass spectrometry and liquid chromatography techniques that enable us to perform high-resolution peptide analysis and identify proteolytic events with precision.
- Customized solutions: We specialize in bespoke solutions tailored to the specific requirements of PROTAC research. We work closely with our clients to design experiments and provide comprehensive data analysis.
- Timely and efficient service: Our company takes pride in delivering prompt results, ensuring that our clients receive the necessary data and insights to drive their PROTAC research forward.
- Comprehensive data analysis: In addition to providing raw data, we offer an extensive analysis and interpretation of the data collected from peptidomics experiments. This assistance helps our clients derive meaningful conclusions from their research.
At Creative Proteomics, our commitment lies in empowering researchers, pharmaceutical developers, and biotechnologists with the most advanced peptidomics analysis techniques available. Through our services, we aim to accelerate advancements in animal health, drug development, and basic biological research. Please contact us today and unlock the potential of peptide analysis.
* For research use only. Not for use in diagnostic procedures!
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