Creative Proteomics is dedicated to providing exceptional peptide biomarker identification services. Through professional technical means and efficient service processes, we provide accurate and rapid services of peptide biomarker identification to researchers and developers around the world. We are committed to helping customers better understand the role of peptide biomarkers in life processes.
What is Peptide Biomarker?
Biomarkers act as important indicators, allowing us to assess normal biology, identify pathological changes, and gauge responses to medical treatments. Peptides are well-suited to serve as biomarkers given their ability to move between different tissues and fluids throughout the organism. By analyzing variations in peptide profiles detected from accessible sample types like blood or urine, we may be able to see reflections of pathogenic processes occurring in other organs or systems.
How Do We Identify Peptide Biomarkers?
Creative Proteomics uses the most advanced instruments and equipment, such as mass spectrometers (MS) and chromatographs, as well as professional experimental protocols to isolate, purify, quantitatively and qualitatively analyze peptides in biological samples. In addition, we can also use the latest bioinformatics methods to perform functional prediction and molecular mechanism analysis of the identified peptides.
Relative Quantification Analysis
At Creative Proteomics, we utilize relative quantitative analysis to infer differences in peptide expression between samples. We compare characteristics like peak intensity, area, or number of peptides detected. By analyzing variations in these metrics, we can draw conclusions about a peptide's relative abundance across samples studied under diverse conditions. The insights gained provide a deeper grasp of how biological systems adjust at the protein level.
Difference Analysis
Peptides that demonstrate much higher or lower levels depending on the sample could serve as promising leads for biomarker development. Identifying signatures that strongly change based on the sample studied provides targets for further exploring potential biomarkers relevant to specific physiological or pathological states.
Our Peptide Biomarker Identification Process
Sample pre-treatment steps are performed by us to extract, enrich or purify the biomarkers of interest.
LC-MS Analysis
A core technology in our work is LC-MS, an indispensable tool that enables comprehensive profiling of peptidomics. With LC-MS, we can not only detect and quantify peptides, but also comparatively assess changes in abundance across sample groups.
Data Processing
MS generates large amounts of data, which we use professional bioinformatics tools and software to process and analyze. Through database searches, spectral matching and statistical analysis, we help clients identify potential biomarkers and assess their significance.
Biomarker Characterization
After validating a potential biomarker candidate, our team seeks to further elucidate its significance and functionality. We aim to understand how these biomarkers fit into biological systems and pathways. Gaining such contextual insights allows us to explore promising applications.
Sample Types for Peptide Biomarker Identification
Common sample types used for peptide biomarker identification include blood (serum, plasma), urine, tissue, and cerebrospinal fluid (CSF). The choice of sample type depends on the target disease or condition.
Application of Our Peptide Biomarker Identification Service
- Help researchers better understand the functions and regulatory mechanisms of biological systems.
- Provide references for disease diagnosis and prognosis.
- Guide drug development and production.
- Discover new therapeutic targets and drug candidates.
- Improve research reliability and reproducibility.
Advantages of Our Peptide Biomarker Identification Services
At Creative Proteomics, peptidomics exploration relies on a cutting-edge LC-MS platform featuring nanoLC coupled with an Orbitrap Fusion Lumos mass spectrometer.
- With high sensitivity and specificity and rapid detection speeds, we can obtain accurate mass measurements across comprehensive samples. The Orbitrap technology delivers unparalleled resolution for confident identification of biomarkers from complex proteomic mixtures.
- Our high throughput capabilities allow accelerated analyses of multiple cohorts.
- Combined with our expertise, we can extensively survey the biomolecules influential in human health and disease.
- Our versatile suite of MS tools provides insights applicable to a diverse scope of research areas.
Whether you have a specific research question, require assistance with study design, or need guidance on peptide biomarker analysis, Creative Proteomics is ready to support you. Contact us today to discuss your peptide biomarker identification needs and discover how our expertise can contribute to your research success!
* For research use only. Not for use in diagnostic procedures!
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