About Creative Proteomics

Peptidomics and Peptide Analysis for Research and Development

Creative Proteomics is a mass spectrometry-based contract research organization supporting academic, biotechnology, and pharmaceutical R&D with peptidomics and peptide analysis. We design study-specific workflows for peptide discovery, characterization, quantification, immunopeptidomics, targeted bioanalysis, and bioinformatics.

Mass Spectrometry-Based CRO
Peptide-Focused Workflows
Academic & Biopharma R&D

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Organization TypeMass Spectrometry-Based CRO

Scientific FocusPeptidomics & Peptide Analysis

Project ApproachStudy-Specific Research Workflows

Primary AudienceAcademic, Biotechnology & Pharmaceutical R&D

Who We Are

Peptide-Focused Research Support

Peptide analysis has analytical requirements that differ from conventional bottom-up proteomics. Endogenous processing, degradation, adsorption, post-translational modifications, abundance range, and sequence diversity can influence how samples are collected, prepared, separated, acquired, and interpreted.

Our projects therefore begin with the research question and the evidence required. Sample matrix, peptide class, available material, study design, and downstream use are considered before the analytical route is selected.

Core FieldPeptidomics and peptide analysis for research applications

Analytical FoundationMass spectrometry and LC-MS/MS with project-specific sample preparation, acquisition, quantification, and data analysis

Project ScopeDiscovery, characterization, quantification, immunopeptidomics, targeted bioanalysis, and bioinformatics

Project ApproachSupport from feasibility and study design through analysis, data processing, and reporting

Peptide-Specific Expertise

Why Peptide-Focused Workflows Matter

Peptide studies can be particularly sensitive to sample handling and acquisition choices. The workflow is selected around the analyte and the evidence the study must produce.

Preserve the Native Peptide Profile

Where relevant, sample handling accounts for ex vivo proteolysis, degradation, adsorption, matrix effects, and stabilization requirements that can alter the measured peptide population.

Select the MS Strategy for the Evidence Needed

Discovery LC-MS/MS, DIA, targeted PRM/MRM, de novo sequencing, and structure-focused approaches are selected according to whether the study requires breadth, comparison, confirmation, quantification, or structural detail.

Interpret Peptides in Biological Context

Analysis can integrate peptide sequence, precursor or source protein, cleavage pattern, abundance, PTM state, motif, pathway, interaction, and complementary omics context as appropriate to the study.

Project Support

How We Support Peptidomics Projects

Support can begin at feasibility and study design and continue through analysis, data processing, and reporting.

Scientific Consultation

Define the biological question, sample type, study groups, available material, and the evidence required from the study.

Study-Specific Design

Select sample handling, enrichment or fractionation, acquisition, quantification, and bioinformatics strategies appropriate to the project.

Quality Control

Build in project-appropriate controls, pooled QC or replicates, identification criteria, and targeted-assay checks where applicable.

Data and Reporting

Deliver project-appropriate raw data, identification or quantification tables, QC summaries, statistical outputs, visualizations, and reports.

Who We Work With

Research Teams We Support

We work with research teams that need peptide-level evidence across exploratory, mechanistic, and development-stage R&D.

Academic Research TeamsEndogenous peptide biology, signaling, processing, antigen presentation, disease-model research, biomarker discovery, and method development.

Biotechnology R&DDiscovery, platform development, peptide engineering, biomarker research, and translational R&D.

Pharmaceutical R&DPeptide drug discovery and development, immunopeptidomics, targeted quantification, PK/PD bioanalysis, and related research applications.

Selected Organizations

Selected Research Organizations We Have Supported

Creative Proteomics has supported research and R&D teams at academic medical centers, universities, biotechnology companies, and biopharmaceutical organizations.

Customer Publications

Selected Customer Publications

Selected peer-reviewed studies documenting Creative Proteomics support in peptidomics, peptide sequencing, or peptide-level mass spectrometry.

Journal of Clinical Investigation2025

Carboxypeptidase D Deficiency Causes Hearing Loss Amenable to Treatment

Creative Proteomics Support

Peptidomics analysis at Creative Proteomics was used to support assessment of impaired carboxypeptidase D activity.

Frontiers in Microbiology2025

The Anti-Biofilm Compound 4-Ethoxybenzoic Acid Inhibits Staphylococcus aureus Virulence Factor Production via a Putative 4EB-Binding Pocket in Key Virulence-Associated Proteins

Creative Proteomics Support

The study reports nanoLC-MS/MS sequencing at Creative Proteomics for amino-acid sequence determination and peptide-mapping-based sequence assembly.

Biochemistry and Biophysics Reports2022

Isolation of the Mustard Napin Protein Allergen Sin a 1 and Characterisation of Its Antifungal Activity

Creative Proteomics Support

De novo sequencing was carried out commercially by Creative Proteomics using multi-enzyme digestion, nano LC-MS/MS, and PEAKS Studio.

Microorganisms2024

In Vitro Identification of Phosphorylation Sites on TcPolβ by Protein Kinases TcCK1, TcCK2, TcAUK1, and TcPKC1 and Effect of Phorbol Ester on Activation by TcPKC of TcPolβ in Trypanosoma cruzi Epimastigotes

Creative Proteomics Support

Phosphorylated TcPolβ bands were sent to Creative Proteomics for phosphopeptide and phosphorylation-site analysis by NanoLC-MS/MS.

Explore More

Explore Peptidomics at Creative Proteomics

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Capabilities

Peptidomics Services

Browse current capabilities across discovery, characterization, immunopeptidomics, neuropeptidomics, quantification, and bioanalysis.

Research Resources

Peptidomics Knowledge Center

Read technical resources on peptidomics methods, study design, and data interpretation.

Planning a Peptidomics Project?

Tell us your research question, sample type, study design, and analytical goals. Our team can discuss feasibility and a suitable analytical approach.

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