At Creative Proteomics, we are at the forefront of peptidomics-based drug discovery, harnessing state-of-the-art techniques and instrumentation to unlock the vast potential of peptide-based therapeutics. Our commitment to advancing the frontiers of drug discovery through peptidomics is unparalleled, and we stand ready to collaborate with pharmaceutical companies, research institutions, and academia to bring novel peptide-based drugs to the market.
Peptidomics-Based Drug Discovery Solutions
Peptidomics-based drug discovery is an innovative approach that focuses on the identification and characterization of peptides and peptide-derived compounds present in biological samples. Peptides are short chains of amino acids that play crucial roles in various physiological processes, making them excellent targets for drug development. By studying the peptide profiles and modifications within biological systems, researchers can uncover potential leads for the development of novel therapeutics.
- Pharmacopeptidomics Research
Pharmacopeptidomics analysis involves a multifaceted approach, delving into the identification, quantification, and characterization of peptides, thereby offering pivotal insights into their roles in physiological processes and therapeutic interventions. Our cutting-edge services cater to the intricate requirements of pharmacopeptidomics, delivering precise, reliable, and exhaustive analysis for pharmaceutical and biotechnological applications.
- Peptidomics-Based Drug Target Research
At Creative Proteomics, we are at the forefront of peptidomics-based drug target research, harnessing advanced methodologies and cutting-edge technologies to drive innovation in the field of drug development.
- Peptide-Based Therapeutic Development
- Drug Repurposing
- Identifying New Drug Targets
- Peptidomics-Based Drug Side Effects Research
By applying peptidomics to investigate drug side effects, our researchers can gain a deeper understanding of the intricate peptide interactions within the body when exposed to pharmaceutical compounds.
- Mechanism of Action Elucidation
- Prediction of Drug Response
- Adverse Event Monitoring
- Peptidomics-Based Drug Off-Target Effects Research
Our approach encompasses a thorough understanding of peptidomes in biological systems, leading to the identification and characterization of potential off-target interactions. By employing state-of-the-art methodologies, we aim to assist pharmaceutical developers in minimizing the risks associated with off-target effects while optimizing drug efficacy.
- Development of New Polypeptide Prodrugs
We conduct extensive physicochemical analysis to evaluate the physical and chemical properties of the prodrugs. This includes solubility studies, stability assessment, molecular weight determination, validation of chemical purity, and structural analysis using techniques like HPLC, LC-MS, NMR, and more.
- Peptide Drug Quality Control
At Creative Proteomics, we recognize the critical role played by quality control in ensuring the consistent performance and safety of peptide drugs. Utilizing HPLC, we can effectively analyze peptide purity, sequence confirmation, and detect impurities at trace levels.
What We Offer?
| Peptide Identification and Characterization |
Bioactivity Assessment |
Drug Development Support |
| Leveraging advanced mass spectrometry and bioinformatics tools, we identify and characterize endogenous peptides, elucidating their sequences, structures, and potential bioactivities. |
Through sophisticated in vitro and in vivo assays, we assess the functional properties of bioactive peptides to evaluate their therapeutic potential. |
We offer tailored support in peptide-based drug development, from lead optimization to preclinical studies, enabling seamless progression towards clinical applications. |
Techniques and Instrumentation for Peptidomics-Based Drug Discovery
- Data-Independent Acquisition (DIA)
DIA methodologies offer comprehensive peptide profiling and quantification, allowing for a deeper understanding of the peptidome within biological samples.
- Bioinformatics and Computational Tools
Leveraging sophisticated bioinformatics pipelines and databases, we perform in-depth data analysis, peptide sequencing, and functional annotation, enabling the translation of raw data into meaningful biological insights.
- Activity-Based Protein Profiling (ABPP)
This technique facilitates the systematic functional assessment of bioactive peptides, shedding light on their interactions with target proteins and pathways, essential for understanding their therapeutic potential.
- High-Resolution Mass Spectrometry
- Agilent 6550 iFunnel Q-TOF
- Shimadzu LCMS-9030 Q-TOF
- AccuTOF GCx
- AccuTOF-SRM
- AxION 2 TOF
- AxION iQT
At Creative Proteomics, our commitment lies in empowering researchers, pharmaceutical developers, and biotechnologists with the most advanced peptidomics analysis techniques available. Through our services, we aim to accelerate advancements in animal health, drug development, and basic biological research. Please contact us today and unlock the potential of peptide analysis.
* For research use only. Not for use in diagnostic procedures!
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