Mass Spectrometry-Based Peptidomics CRO

Peptidomics Services for Peptide Discovery, Immunopeptidomics, and Quantitative Bioanalysis

Creative Proteomics supports academic, biotechnology, and pharmaceutical R&D with peptide-focused LC-MS/MS workflows spanning endogenous peptide discovery, HLA immunopeptidomics, neuropeptidomics, peptide characterization, quantitative peptidomics, and therapeutic peptide bioanalysis.

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Key Research Areas

Peptidomics Workflows for Distinct Research Questions

Access dedicated workflows for antigen presentation, neuropeptide biology, endogenous peptide discovery, and quantitative bioanalysis, supported by complementary characterization and application-focused services.

Antigen Presentation

Immunopeptidomics

Profile HLA- or MHC-bound peptides, identify candidate tumor-associated and non-canonical antigens, prioritize candidate epitopes, and support downstream immunogenicity assessment and TCR-pMHC validation.

HLA Peptidomics Neoantigen Discovery MAPPs Immunogenicity Assessment

Neuropeptide Biology

Neuropeptidomics

Characterize neuropeptide diversity across tissues, biofluids, and model systems using untargeted profiling, spatially resolved analysis, single-cell peptidomics, CNS biomarker workflows, and targeted quantification.

Untargeted Neuropeptidomics Spatial Neuropeptidomics CNS Peptide Biomarker Discovery

Discovery

Peptide Discovery

Discover endogenous and bioactive peptides across biological samples, proteolytic products, natural products, and venoms, with dedicated spatial and single-cell peptidomics workflows.

Endogenous Peptidomics Peptide Biomarker Discovery Spatial Peptidomics Single-Cell Peptidomics

Quantification

Quantification & Bioanalysis

Support comparative and targeted studies with relative quantification, PRM/MRM, absolute quantification, biomarker validation, peptide hormone panels, and therapeutic peptide PK/PD or ADME bioanalysis.

DIA Peptidomics PRM Quantification Peptide PK/PD & ADME

Find Your Project Route

Start With the Evidence Your Study Needs

Choose the route that best matches your biological question, analytical objective, or quantitative endpoint.

What peptides are present?

Untargeted endogenous peptide discovery, shotgun peptidomics, sample-specific peptide profiling, and biomarker-oriented discovery.

Peptide Discovery Services

Which peptides are naturally presented by HLA?

HLA ligandome profiling, MHC-binding peptide screening, neoantigen discovery, and downstream antigen validation.

HLA Peptidomics

How does the neuropeptidome change?

Untargeted neuropeptide profiling, CNS biomarker discovery, spatially resolved analysis, single-cell peptidomics, and functional or dynamic studies.

Neuropeptidomics

How can the peptide be identified and characterized?

Sequence determination, molecular mass, amino acid composition, purity, PTMs, disulfide bonds, secondary structure, and interaction analysis.

Peptide Characterization

How much peptide is present?

Relative quantification by label-free or DIA workflows, absolute quantification, PRM/MRM assays, and biomarker validation.

Quantification & Bioanalysis

How can peptide data support R&D?

Peptide drug discovery, disease-mechanism studies, and applied research in food, nutrition, and cosmetic peptides.

Research Solutions

Analytical Strategies

Integrated Peptide Discovery, Characterization, and Quantification

Combine untargeted discovery, sequence and PTM characterization, relative and targeted quantification, and bioinformatics within a study-specific analytical strategy.

Discovery MSUntargeted peptide profiling and identification

DIASystematic relative quantification across comparative studies

PRM / MRMTargeted confirmation and quantitative assays

Sequence & PTM CharacterizationSequence, termini, PTMs, and disulfide-bond evidence

BioinformaticsQC, annotation, statistics and multi-omics integration

Featured Services

Featured Peptidomics Workflows

Explore dedicated services for HLA ligandome profiling, spatial and single-cell neuropeptidomics, DIA-based quantification, degradomics and terminomics, biofluid peptidomics, and therapeutic peptide bioanalysis.

Immunopeptidomics

HLA Peptidomics & Neoantigen Discovery

HLA ligandome profiling, antigen discovery, candidate prioritization, and downstream validation for immunology and oncology research.

Neuropeptidomics

Spatial Neuropeptidomics & Single-Cell Neuropeptidomics

Map neuropeptide distributions across anatomical regions and characterize peptide heterogeneity in individual cells, complementing bulk measurements.

Quantification

DIA Peptidomics

Apply data-independent acquisition for systematic peptide sampling and consistent relative quantification across comparative studies and larger sample sets.

Proteolysis

Degradomics & N-/C-Terminomics

Map proteolytic cleavage sites, peptide termini, and protease-substrate relationships to investigate protease activity and processing mechanisms.

Biofluids

Plasma & Serum Peptidomics

Profile circulating peptides with controlled preanalytical handling, discovery workflows, and targeted follow-up for biomarker studies.

Targeted Bioanalysis

Therapeutic Peptide PK/PD & ADME

Support therapeutic peptide programs with quantitative bioanalysis for exposure assessment, PK/PD studies, metabolic stability, and ADME characterization.

Project Workflow

From Study Design to Interpretable Peptide Data

Projects progress from a defined research question and sample context through peptide-specific preparation, mass spectrometric acquisition, quality control, and data interpretation.

Study definition

Define the research question and evidence requirements

Start with the biological question, sample matrix, comparison structure, and the level of identification or quantitative evidence needed to support the study objective.

InputsResearch objective

Clarify the biological question, intended comparison, and downstream use of the data.

DecisionsSample and evidence context

Review matrix, cohort structure, abundance range, modifications, and confidence requirements.

DeliverableAnalytical study brief

Align scope, sample requirements, controls, endpoints, and reporting expectations.

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Research Solutions

Peptidomics Across Research and Development

Apply peptide-level evidence to drug discovery, disease biology, and applied research in food, nutrition, and cosmetic peptides.

Drug Discovery

Drug Discovery & Development

Use peptidomics and peptide bioanalysis to support candidate discovery, therapeutic peptide characterization, PK/PD or ADME studies, and emerging peptide modalities.

Mechanism

Disease & Mechanism

Investigate how peptide changes and proteolytic processing relate to disease mechanisms and biological pathways.

Applied Research

Food & Nutrition & Cosmetic Peptides

Characterize bioactive peptides, fermentation-derived peptides, and peptide ingredients in application-focused R&D.

Peptide-Focused Approach

Designed Around the Analytical Challenges of Peptides

Peptide measurements are sensitive to preanalytical handling, proteolysis, adsorption, matrix effects, abundance, and sequence or modification state. These variables should be considered from the start of study design.

Peptide-Focused Study Design

Workflow selection begins with sample type, peptide biology, expected abundance, required evidence, and downstream use of the data.

Complementary Analytical Routes

Discovery, sequencing, structural characterization, DIA, targeted quantification and bioinformatics can be combined when appropriate.

Defined QC & Reporting

QC checkpoints and reporting outputs are planned as part of the workflow rather than added only after data acquisition.

Scientific Project Support

Project planning can address feasibility, sample requirements, analytical strategy, and interpretation before and after data acquisition.

Resources

Peptidomics Resources for Study Planning

Explore guides, method comparisons, and experimental-design resources covering sample handling, workflow selection, quantitative strategies, and interpretation of peptide-level data.

Peptidomics Guides & Infographics

Project Planning

Need Help Selecting a Workflow?

Share your research question, sample type, and intended comparison. We can help identify an analytical route suited to your study.

Discuss Feasibility →

Planning a Peptidomics Study?

Tell us what you need to discover, characterize, or quantify. We can discuss sample requirements, analytical strategy, and the workflow best suited to your study.

Discuss Your Project →

Peptidomics Services for Peptide Discovery, Immunopeptidomics, and Quantitative Bioanalysis

Peptidomics Workflows for Distinct Research Questions

Immunopeptidomics

Neuropeptidomics

Peptide Discovery

Quantification & Bioanalysis

Start With the Evidence Your Study Needs

What peptides are present?

Which peptides are naturally presented by HLA?

How does the neuropeptidome change?

How can the peptide be identified and characterized?

How much peptide is present?

How can peptide data support R&D?

Integrated Peptide Discovery, Characterization, and Quantification

Featured Peptidomics Workflows

HLA Peptidomics & Neoantigen Discovery

Spatial Neuropeptidomics & Single-Cell Neuropeptidomics

DIA Peptidomics

Degradomics & N-/C-Terminomics

Plasma & Serum Peptidomics

Therapeutic Peptide PK/PD & ADME

From Study Design to Interpretable Peptide Data

Define the research question and evidence requirements

Select the analytical workflow

Plan peptide-specific sample preparation

Acquire LC-MS/MS data with defined quality controls

Analyze, quality-check, and report peptide-level results

Peptidomics Across Research and Development

Drug Discovery & Development

Disease & Mechanism

Food & Nutrition & Cosmetic Peptides

Designed Around the Analytical Challenges of Peptides

Peptidomics Resources for Study Planning

Need Help Selecting a Workflow?

Planning a Peptidomics Study?