Introduction
Peptidomics is a relatively new and often overlooked branch of proteomics that targets biologically active substances
involved in various cellular functions in an organism, including cytokines, growth hormones, and disease-specific
proteins of certain proteins in body fluids. They are related to the regulation of organisms, including hormone
regulation, neurotransmitter regulation, cell growth and proliferation regulation, and immune regulation. Studying
the structure and physiological function of peptides is of great significance in life sciences.
Currently, MS-based methods provide an efficient toolset for the discovery and characterization of peptides in
biological samples. Due to its high sensitivity, multiplex detection, small sample size, and compatibility with
multiple sampling methods and complementary measurement techniques, MS allows a wide range of quantitative and
qualitative studies from the organismal to the single-cell level.
Fig. 1. General methods of peptidomics. (Michael
S, et al., 2014)
Our Services
Peptidomics is a branch of proteomics. With first-class analysis experience in protein sequencing and proteomics,
Creative Proteomics has established an advanced peptidomics analysis platform, combining mass
spectrometry and bioinformatics analysis to make peptidomics analysis possible, and the detected peptides are
identified by de novo sequencing or database search by tandem mass spectrometer.
Experimental Process
Fig. 2. Experimental
process of our peptidomic analysis services.
At Creative Proteomics, we provide the following peptidomic analysis services, but not limited to.
Advantages of Our Peptidomic Analysis Services
- One-stop service: We can provide complete steps from isolation and enrichment of endogenous peptides to peptide
identification and subsequent data analysis.
- Extremely high accuracy: MS-based accurate peptide sequence identification.
- High enrichment efficiency: More than 99% of proteins are removed during sample processing.
- Comprehensive service capabilities: Including complete computational proteomics analysis and corresponding
biological information, covering a wide range of data interpretation.
*Note: We also offer custom analysis services. For special requirements, please contact us for project discussion.
Applications
Our peptidomic analysis can be applied in various fields, including but not limited to:
- Biomarker discovery/validation: Identify and validate potential disease biomarkers or drug targets.
- Side effect detection: Detection of non-specific and unwanted drug effects such as degradation.
- Endogenous peptide identification: Identify hormones and other signaling molecules in the body, etc., so as to
predict the hormone function of new endogenous peptides.
- Sample quality control: Peptides as degradation products can indicate the quality of the sample,
- Digestive peptidomics: Study how dietary proteins are catabolized in the digestive system and throughout the
body
- Peptidomics of food hydrolyzates: Determine the peptides produced during the hydrolysis of food.
- Development of novel peptide prodrugs.
Which Sample Types Can be Analysed?
- Animal and clinical tissue specimens.
- Serum, plasma and saliva.
- Body fluids (serum/plasma, CSF and urine).
- Cells.
- Culture supernatant.
- Customized sample types.
Creative Proteomics is a trusted provider of proteomics analysis services. Thanks to our outstanding
scientists and powerful mass spectrometry platform, we offer a range of peptidomic analysis services to our clients
worldwile. Our services guarantee accurate and reliable results, at quick turnaround time! If you have any questions
or specific requirements, please feel free to contact us. We will fulfill
your goal.
References
- Wei X, Li L J. (2009). Mass spectrometry-based proteomics and peptidomics for biomarker discovery in
neurodegenerative diseases. Int J Clin Exp Pathol. 2(2):132-148.
- Michael S, Peter S K, Lloyd D. et al. (2014) Historical perspective of peptidomics. EuPA Open
Proteomics. 3:171-182,
