Identification of Peptide Biomarkers Service

Identification of Peptide Biomarkers Service

Service Details


A biomarker is a characteristic that can be measured and evaluated as an indicator of normal biological processes, pathological processes, or pharmacological responses to therapeutic interventions. It can explore the pathogenesis at the molecular level, but also has unique advantages in accurately and sensitively evaluating early and low-level damage, which can provide early warning and provide clinicians with a basis for auxiliary diagnosis to a large extent. As a terminal substitute, biomarkers are helpful for the research and development of target drugs. Interestingly, peptides are ideal biomarker candidates due to their multiple involvement in biological systems, which can migrate between various parts of the organism, so many pathogenic processes can be reflected by the characteristics and pathological changes of the polypeptide composition in different body fluids, and the changes in the abundance of polypeptides related to various diseases can be detected.

Fig. 1. Overview of the workflow of MS-based proteomics/peptidomics for biomarker discovery.Fig. 1. Overview of the workflow of MS-based proteomics/peptidomics for biomarker discovery. (Wei X, et al., 2009)

Our Services

The discovery of biomarkers can help greatly facilitate the interpretation of clinical trial results. Creative Proteomics develops and validates biomarker assays according to FDA/EMA guidelines to minimize technical variability and ensure maximum reproducibility. Thanks to our high-sensitivity detection mass spectrometry, we provide high-quality peptide biomarker identification services to customers around the world.

Here, our lab technicians offer two common modes of peptide biomarker development: pattern recognition and single/polybiomarker assays.

  • Pattern recognition method: The final information can be obtained only by relying on the high specificity and sensitivity of MS, without obtaining the identity information of candidate biomarkers.
  • Single/polybiomarker assays: This method is more practical and reliable than pattern recognition because peptide differences in polypeptide expression levels can be verified from collected biological samples from different sourcess. This analytical method can simultaneously reveal the concentration of analyte molecules with very high specificity, thanks to the precise macromolecular mass and sequencing capability.

Creative Proteomics have developed a complete workflow for mass spectrometry-based peptidomic biomarker discovery.

  • Sample preparation.
  • Separation of protein/peptide samples.
  • Identification of proteins/peptides by MS or tandem MS.
  • Data processing for bioinformatics tools.
  • Validation of results by alternative techniques.

Our peptide biomarker identification service performs two steps simultaneously: identifying the peptides present in a sample (qualitative) and determining the corresponding concentrations (quantitative). Our expert team screens the best candidate peptides for customers by combining the two. Throughout the analysis process, mass spectrometry technology with high resolution, high sensitivity, high throughput and quantitative functions is combined with liquid chromatography (such as UPLC and nano-LC) to provide the most accurate analysis results.

Our peptide biomarker identification service offers the following tests according to validated guidelines, including but not limited to.

  • Standard Curve
  • Accuracy and Precision
  • Stable
  • Linearity
  • Parallelism
  • Selectivity and Specificity
  • Reproducibility

Advantages of Our Identification of Peptide Biomarkers Service

  • Solve problems with expertise and creativity.
  • Responsive project management.
  • Rich experience in screening peptide drugs.
  • Peptide expertise in a wide range of therapeutic disease areas.
  • Customized service.

Creative Proteomics is a trusted provider of proteomics analysis services. Thanks to our outstanding scientists and powerful mass spectrometry platform, we offer comprehensive and high-quality identification of peptide biomarkers service for global customers. If you have any questions or specific requirements, please feel free to contact us. We will fulfill your goal.


  1. Wei X, Li L J. (2009). Mass spectrometry-based proteomics and peptidomics for biomarker discovery in neurodegenerative diseases. Int J Clin Exp Pathol. 2(2):132-148.

For research use only, not intended for any clinical use.

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