Byonic Software
Byonic is a software that specially used to identify peptide and protein sequences obtained by tandem mass
spectrometry. The feature of Byonic software is that it is specially optimized for the complex modification search
of peptides, which can be used to search for various combinations of modification types, but also can search for
unknown modifications within a certain range through the "Wildcard Search™" mode. In addition, Byonic can
perform a glycopeptide search, which allows users to identify glycopeptides without prior knowledge of glycan masses
or glycosylation sites. Notablely, wildcard search allow Byonic to focus its efforts on the candidate peptides most
likely to match the mass spectrum, so with the right parameter settings Byonic can find more true peptides faster
than any other proteomics search engine match.
Fig.
1. Workflow of glycoproteomic analysis to identify and quantify glycopeptides by using byonic software. (Sharma A,
et al., 2020)
Our Services
Whether it is for the analysis of complex large-scale proteomics or the analysis of individual protein molecules, the
problem of spectrum identification in the experiment of sample analysis by mass spectrometry has always been one of
the most difficult points. Creative Proteomics provides a series of strategies such as de novo
sequencing, database search, spectral library search, etc., which can be used to achieve different experimental
goals. In addition, peptide samples for macromolecules tend to break regularly from peptide bonds, making the method
based on database search still the most commonly used and best-used strategy.
Byonic software is a complete MS/MS search engine that provides unparalleled sensitivity for comprehensive peptide
and protein identification. As a leading supplier of protein sequencing and mass spectrometry analysis,
Creative Proteomics provides a series of analysis services based on Byonic software, including but
not limited.
- Protein-Protein Interactions
- ADC and DAR Analysis
- Peptide Mapping
- PTM Analysis
- HCP Analysis
- Sequence Variation Analysis
- Epitope Mapping
- De Novo Sequencing
- O-Linked and N-Linked Released Glycans
- Automatic Processing of Fluorescently Labeled Glycans
Features of Byonic Software
- Comprehensive search strategies, including top-down and bottom-up.
- For the fine search strategy of post-translational modification, it can be compatible with dozens of
modification settings at the same time, and the search efficiency also take into account.
- The unique and powerful wildcard search function can perform searches for unknown modifications, thereby helping
to discover new modifications.
- Powerful glycopeptide search function.
- Identification of disulfide bonds and cross-links.
- Sequence variation search and modification site location.
- Almost all data types currently on the market are supported, including CID, TOF-TOF, QTOF HCD, ETD/ECD, EThcD,
etc.
Creative Proteomics provides comprehensive and systematic analysis services based on Byonic software
to meet customer demand. Using our experience in the computational sciences and knowledge of these powerful
technologies, we can provide our customers unparalleled services for the analysis of proteomics data. Please contact us without any hesitation if you have any bioinformatics analysis
requirement.
References
- Bern M, Kil Y J, Becker C. (2012) Byonic: advanced peptide and protein identification software. Curr Protoc
Bioinformatics. Chapter 13:Unit13.20.
- Sharma A, Cox J, Glass J, et al. (2020) Serum glycoproteomic alterations in patients with diabetic
retinopathy. Proteomes. 8(3):25.
