Vaccines are one of the most important biological products. In the process of vaccine development, it is necessary to analyze and determine the structure of the target bacteria or virus target protein.
Proteins in their natural state fold to fit their natural environment and have a uniform structure. However, when the protein is purified, exists in a non-physiological environment or is exposed to physical and chemical stress, the protein will undergo structural changes to adapt to the new environment. These structural changes may lead to changes in molecular solubility, aggregation, surface activity, etc., and eventually lead to degradation, soluble aggregation, and insoluble precipitation. Therefore, in the process of vaccine isolation and purification, it is necessary to protect the natural structure of vaccine antigen as much as possible under the condition of achieving ideal purity.
In all stages of vaccine development, Creative Proteomics can provide you with customized vaccine structural analysis services to help you better control the effectiveness and stability of the vaccine. We are committed to becoming the most trusted biopharmaceutical partner, providing customers with high-quality, professional analysis services. We have a wealth of experience and advanced technology platform to ensure that you get high-quality results analysis reports.
We Can Provide but Not Limited to:
| Service Category | Analytical Method | Details |
| Secondary Structure Analysis | Far UV Circular Dichroism (CD) Spectroscopy Analysis | Obtain the information of the secondary structure of the protein or polypeptide chain according to the far ultraviolet CD spectrum of the measured protein or polypeptide |
| Nuclear Magnetic Resonance (NMR) Spectroscopy | The three-dimensional structure of macromolecules in their natural state can be determined directly in solution. NMR Spectroscopy suitable for biomolecules with small molecular weight. | |
| Tertiary Structure Analysis | Near UV Circular Dichroism Spectroscopy Analysis | Reflect the arrangement information of tryptophan, phenylalanine, tyrosine and other residues of the chromophore of protein side chain and the changes of disulfide bond microenvironment. |
| Hydrogen Deuterium Exchange Mass Spectrometry (HDX-MS) | Detect the structure and conformation information of single proteins and protein complexes, as well as protein-protein or protein-ligand interaction sites, and conformational changes induced by post-translational modification (PTM) in protein complexes. | |
| Ion Mobility Spectrometry Mass Spectrometry (IM-MS) | Analyze complete heterogeneous protein combinations in the gas phase ranging from 10 kDa to 1 MDa. MS can identify and quantitatively analyze the relative abundance of different stoichiometric substances, and obtain the equilibrium constants of potential protein-protein and protein-ligand interactions. IM can also obtain information about the physical size of the protein. |
Advantages of Vaccine Advanced Structure Analysis Service:
➢ Short time-consuming: The service adopts standardized analysis methods and high-efficiency data analysis software. At the same time, it adopts a fast and convenient sample processing procedure, which can greatly reduce the analysis time for vaccine advanced structure.
➢ Professional platform: According to your purpose and budget, we suggest a suitable platform for you to conduct structural analysis.
➢ Rapid turnaround time: 5-7 days to provide complete analysis report.
➢ Customized service: We can provide you with tailor-made services according to your needs, and you can choose the analysis plan you need.
Creative Proteomics' researchers can provide you with detailed experimental analysis programs, complete and comprehensive vaccine advanced structure analysis reports and other bioinformatics analysis reports. We insist on focusing on customer needs and assist biopharmaceutical companies to better complete research projects in terms of technology and analytical solutions to accelerate the marketization of their products.
