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Protein Identification Service

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Protein Identification Service

Proper and complete analysis and characterization of biopharmaceutical proteins is essential to control their safety, purity, potency, stability, and overall quality. Creative Proteomics is a reliable partner of biopharmaceuticals. We will provide customers with reliable protein identification services according to ICH Q6B guidelines to ensure the quality and consistency of your products.

We Can Provide but Not Limited to:

The services we provide mainly include: 1) protein molecular weight determination: obtaining a relatively accurate protein molecular weight by mass spectrometry. The molecular weight of a single or multi-component protein can be detected with a range of 1-1000 KD; 2) protein sequence analysis. When the proteins of interest are not included in any databases or inaccessible, de novo sequencing is especially suit for deciphering the sequence and identifying the protein. Peptide mapping analysis relies on the presence of this protein in the database, and is often used in batch release or stability tests of biological drugs; 3) Protein isoelectric point analysis can be used to determine whether the specificity and precision of biological products meet the verification requirements. The detailed service list is shown in the table below.

Protein Molecular Weight Determination ServiceESI-Q TOF-MS Intact Mass Analysis Service
MALDI-TOF-MS Intact Mass Analysis Service
Protein Sequence Analysis ServiceN-terminal Sequencing Service
C-terminal sequencing and Blocked N-terminal Sequencing with MALDI-ISD
Peptide Mapping Service
Peptide Mass Fingerprinting Service
De Novo Protein Sequencing Service
Amino Acids Analysis Service
Amino Acids Composition Analysis
Extinction Coefficient Determination
Differential Scanning Calorimetric (DSC) Analysis
Protein Isoelectric Point Determination ServiceFlat Gel Isoelectric Focusing IP Analysis Service
Capillary Isoelectric Focusing IP Analysis Service

Advantages of Protein Identification Service:

  • Rich Experience: Our company has been engaged in protein analysis of biopharmaceuticals for 16 years.
  • Professional Platforms: Based on high-resolution (greater than 105), high-quality accuracy (less than 1ppm) mass spectrometry platform to ensure the accuracy of identification results. High-resolution Q Exactive Hybrid Quadrupole-Orbitrap mass spectrometer is available.
  • Bioinformatics Services. Our bioinformatics analysts can help you interpret the final data.
  • Rapid Turnaround Time: 7-10 days to provide comprehensive report.
  • Customized Service: We can customize exclusive solutions for you based on your samples.

Creative Proteomics analytical scientists can provide our clients with a range of services for protein identification. You can choose which of these items to examine for analysis. We provide quick turnaround, clear and concise written reports and customized services to help customers solve analytical and technical problems. Ensure that your biotechnology/biological products meet the test procedures and acceptance criteria.

References

  • Luo Y, Matejic T, et al. Characterization and analysis of biopharmaceutical proteins[M]//Separation Science and Technology. Academic Press, 2011, 10: 283-359.
  • Leurs U, Mistarz U H, Rand K D. Getting to the core of protein pharmaceuticals–comprehensive structure analysis by mass spectrometry. European Journal of Pharmaceutics and Biopharmaceutics, 2015, 93: 95-109.

*For Research Use Only. Not for use in the treatment or diagnosis of disease.

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