Vaccines Analysis Service

Vaccines Analysis Service

Vaccines have historically been the most effective means to provide active acquired immunity and fight against infectious diseases. Nowadays, vaccines have been developed either as a prophylactic treatment to provide active acquired immunity or as a therapeutic. A vaccine typically contains an agent that stimulates the body's immune system to recognize the agent as a threat, destroy it, and keep memory of it. These agents are commonly based onpurified protein antigens from natural origin or produced by recombinant DNA, polysaccharides, semi-synthetic poly- or oligosaccharide-protein conjugates and novel nucleic acid constructs.

Vaccines Analysis Service

Vaccines can be classified into different types that represent different strategies used to reduce risk of illness, while retaining the ability to induce a beneficial immune response.It includes live attenuated vaccines, inactivated vaccines, subunit vaccines, toxoid vaccines, conjugate vaccines, DNA vaccines and recombinant vector vaccines. Live attenuated vaccines contain the live form of the virus that are not pathogenic but are able to induce an immune response.While inactivated vaccines contains viruses which have lost their ability to replicate and in order for it to bring about a response it contains more antigen than live vaccines.Besides that, efforts to develop effective vaccines also involve the use of adjuvants, which are formulated as part of a vaccine to enhance its ability to induce protection against infection.

Vaccine Analysis Services at Pronalyse:

Service CategoryServiceMethod
Vaccine IdentificationMolecular WeightESI-QTOF-MS
MALDI-TOF-MS
Sequence AnalysisN-Terminal Sequencing
C-Terminal Sequencing
Peptide Mapping
Amino Acid Analysis
Isoelectric PointFlat Gel Isoelectric Focusing
Capillary Isoelectric Focusing
Vaccine Homogeneity AnalysisVaccine Purity AnalysisSDS-PAGE
Vaccine Polymer AnalysisSize Exclusion Chromatography (SEC)
Vaccine Fragment AnalysisReversed-phase Chromatography (RP)
Vaccine Isoform AnalysisCapillary Isoelectric Focusing
Vaccine Modification AnalysisGlycosylation AnalysisGlycosylation Analysis
Phosphorylation AnalysisPhosphorylation Analysis
Deamidation and Oxidation AnalysisDeamidation and Oxidation analysis
Disulfide Bridges & Free Sulfhydryl GroupsDisulfide Bridges & Free Sulfhydryl Groups Analysis
Advanced Structure AnalysisSecondary StructureCircular Dichroism Spectroscopy (Far UV)
Tertiary StructureCircular Dichroism Spectroscopy (Near UV)
Hydrogen Deuterium Exchange Mass Spectrometry (HDX-MS)
Drug Metabolism and Pharmacokinetic AnalysisMetabolites IsolationColumn Chromatography
Thin Layer Chromatography
Gas Chromatography
High Performance Liquid Chromatography
Structural Analysis of MetabolitesNuclear Magnetic Resonance (NMR) Spectroscopy
Metabolites TrackingIsotopic Labeling Assay
Immunological TestEnzyme-linked immunosorbent assay (ELISA)
Radioimmunoassay (RIA)
Surface Plasmon Resonance (SPR)
Flow Cytometry

Part of the vaccines approved by the US FDA since 1996

ProductManufacturerIndication(s)Approval date
Vaxchora (Cholera Vaccine, Live, Oral)PaxVaxFor active immunization against Cholera2016
Bexsero (Meningococcal Group B Vaccine)NovartisFor the treatment of invasive meningococcal disease caused by serogroup B2015
Flublok (seasonal influenza vaccine)Protein SciencesFor the active immunization against influenza virus subtypes A and type B2013
VariZIG, Varicella Zoster Immune Globulin (Human)CangeneFor the post-exposure prophylaxis of varicella zoster (chickenpox)2013
Flucelvax, Influenza Virus VaccineNovartisFor the treatment of influenza virus subtypes A and type B2012
Horizant (gabapentin enacarbil)GlaxoSmithKlineFor the treatment of postherpetic neuralgia2012
Horizant (gabapentin enacarbil)GlaxoSmithKlineFor the treatment of restless legs syndrome2011
Menveo (meningitis vaccine)NovartisFor the active immunization to prevent invasive meningococcal disease2010
Prevnar 13 (Pneumococcal 13-valent Conjugate Vaccine)WyethFor the active immunization for the prevention of invasive disease caused by Streptococcus pneumoniae2010
Teflaro (ceftarolinefosamil)CerexaFor the treatment of bacterial skin infections and bacterial pneumonia2010
Hiberix (Haemophilus b Conjugate Vaccine; Tetanus Toxoid Conjugate)GlaxoSmithKlineFor the prevention of invasive disease caused by Haemophilusinfluenzae type b2009
FluMist ( Influenza Virus Vaccine)MedImmuneFor the prevention of disease caused by influenza A and B viruses2003
Fluzone Preservative-freeSanofi PasteurPreservative free, pediatric dose, influenza virus vaccine for the immunization of infants2002
Neurontin (gabapentin)PfizerOral treatment for the management of post-herpetic neuralgia (PHN)2002
Pediarix VaccineGlaxoSmithKlineor the prevention of diphtheria, tetanus, pertussi, polio and hepatitis B in children 6 weeks to 7 years old.2002
Avelox I.V. (moxifloxacinhydrochloride)BayerInjectable antibacterial agent for adults with susceptible strains of bacterial infections2001
InvanzMerckOnce-daily injectable treatment for bacterial infections2001
SpectracefTAP PharmaceuticalsOral tablets for the treatment of mild to moderate bacterial infections2001
TwinrixGlaxoSmithKlineFor the prevention of hepatitis A and B2001
Cefazolin and Dextrose USPB Braun MedicalRespiratory tract infections2000
Synercid I.V.Rhone Poulenc Rorerquinupristin and dalfopristin for injection1999
Tamiflu capsuleRocheOseltamivir phosphate capsule1999
OmnicefWarner-LambertTreatment against various bacterias1997
TrovanPfizerTreatment for bacterial infections1997
Zagam (sparfloxacin) tabletsRhone Poulenc RorerTreatment for community-acquired pneumonia (CAP) and chronic bronchitis1997
Augmentin (amoxicillin/clavulanate)ßSmithKline BeechamTreatment for infections involving drug-resistant bacteria1996
HavrixSmithKline BeechamTreatment for hepatitis A1996
Merrem I.V. (meropenem)AstraZenecaTreatment for intra-abdominal infections and bacterial meningitis1996
Tripedia (Diptheria and Tetanus Toxoids and Acellular Pertussis Vaccine Absorbed)Connaught LaboratoriesTreatment for whooping cough1996
Zosyn (sterile piperacillin sodium/tazobactam sodium)WyethTreatment for hospital-acquired pneumonia1996

Data adapted from CenterWatch (https://www.centerwatch.com/drug-information/fda-approved-drugs/therapeutic-area/33/vaccines)

To ensure the safety, efficacy, purity and potency of vaccine products, Pronalyse's analytical scientists are highly experienced and knowledgeable in the comprehensive analysis of vaccine characterization and release, formulation development, and stability testing, adjuvants components and much more. Experience, fast turnaround, clear concise written reports, and custom service are provided in accordance with a wide range of regulatory requirements.

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