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Vaccine Modification Analysis Service

Vaccine verification runs through the various stages of its production, including raw materials, stock solutions, semi-finished products, and finished products. It needs to be tested in terms of physical and chemical properties, safety, and effectiveness. The modification analysis of proteins in vaccines in biopharmaceuticals is an important part of the analysis of vaccine biological activity, stability and quality control.

Amino Acid Analysis Service

At each stage of vaccine development, Creative Proteomics can establish corresponding verification methods and stability verification schemes according to the quality standards of your vaccine products. We have rich experience and advanced technology platform. We are committed to becoming the most trusted biopharmaceutical partner, providing customers with high-quality and professional analysis services. We will use professional protein modification analysis and research methods to ensure that you get high-quality product analysis reports.

We Can Provide but Not Limited to:

 ➢ Glycosylation analysis
 ➢ Phosphorylation analysis
 ➢ Disulfide bridges & free sulfhydryl groups analysis service
 ➢ Deamidation and oxidation analysis
 ➢ Acetylation analysis
 ➢ Methylation analysis
 ➢ Identification of protein post-translational modification sites

Technology Platform of Vaccine Modification Analysis Service:

Creative Proteomics can obtain high-quality and accurate analysis of vaccine modification through matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS) and tandem mass spectrometry, etc.

1) Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS)

The protein samples digested by enzymatic digestion can be analyzed. However, the limitation of this method is that it cannot fully detect all peptide fragments. Some peptides are clearly visible, and some are not visible.

2) Tandem mass spectrometry

In order to more accurately determine the nature of the peptide modification, tandem mass spectrometry (MS/MS) is often used for analysis. After the first MS step, the peptide ions are impacted with inert gas, causing further fragmentation. These peptide fragments are then analyzed in the second MS step. During this process, some of the modified peptides will remain unchanged, and the resulting peptide pattern will be similar to the uncollided peptide in medium. Some peptides will be significantly fragmented, and the resulting peptide pattern can provide further information on the properties and sites of the modified amino acids.

Advantages of Vaccine Modification Analysis Service:

 ➢ Short time-consuming: The service adopts standardized analysis methods and high-efficiency data analysis software. At the same time, it adopts a fast and convenient sample processing procedure, which can greatly reduce the analysis time for vaccine modification.
 ➢ High-throughput and accuracy: The high-throughput mass spectrometry platform can obtain information on the translational modification sites, qualitative and quantitative information of vaccine proteins.
 ➢ Rapid turnaround time: 5-7 days to provide complete analysis report.
 ➢ Customized service: We can provide you with tailor-made services according to your needs, and you can choose the analysis plan you need.

Creative Proteomics' researchers can provide you with detailed experimental analysis programs, complete and comprehensive vaccine modification analysis reports and other bioinformatics analysis reports. We insist on focusing on customer needs and assist biopharmaceutical companies to better complete research projects in terms of technology and analytical solutions to accelerate the marketization of their products.

*For Research Use Only. Not for use in the treatment or diagnosis of disease.

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