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Venom Targeted Therapy in Cancer

Animal venom is a unique natural product, a mixture of protein/peptide and other substances. The analysis of pharmacological and toxicological of the venom components found that it has potential therapeutic effects, such as snake venom, bee venom and scorpion venom, and many animal venoms show excellent anticancer effects. They affect the physiological processes of cancer cells, including cell proliferation and migration, cell apoptosis and the formation of new blood vessels.

Cancer chemotherapy can cause many side effects and result in unsatisfactory therapeutic effects. However, many venom proteins/peptides have been proven to have a good antitumor effect. Specific targeted anticancer agents from venom seem to be a potential tool. Therefore, Creative Proteomics provides customers with services that utilize the natural anti-cancer potential of venom toxins to be applied to cancer targeted therapy.


Cancer is a deadly disease, causing many devastating results to the human body. At present, studies have shown that toxin proteins/peptides of many animal venoms have the highly selective toxicity of a variety of cancer cells, and can exert anticancer effects through different pathways and mechanisms, such as inhibiting cancer cell proliferation, participating in cancer cell apoptosis, and inhibiting new blood vessel formation. Here is some specific information on the use of animal venom to develop anti-cancer drugs.

Animal Venom Venom Component Cancer Cell Type Anti-Cancer Mechanism
Bee venom Melittin Gastric cancer cells Apoptosis of cancer cells through the mitochondrial pathway
Wasp venom Polybia-MPI Prostate and bladder cancer cells Pore formation
Scorpion venom Chlorotoxin Pancreatic cancer cells Inhibition of Cl- conductance that reduces cancer progression
Snake venom PLA2 Microvascular endothelial cells Anti-angiogenesis effect
Snake venom Metalloproteinases Melanoma cells Inhibition of cancer cell proliferation and increased apoptosis
Snake venom Cytotoxins Breast cancer cells Apoptosis through the lysosomal pathway

Our Services

In order to meet customers' new drug treatment needs, we can obtain venom toxins with anti-cancer therapeutic potential through separation, extraction and recombinant synthesis. Through genome, transcriptome, proteome/peptide analysis, more ways can be studied to explore the molecular mechanism and target specificity of venom toxins. We specifically provide:

  • Research on venom composition. Separate and characterize multiple biologically active venom proteins/peptides from your target venom.
  • Structural modification of the sequence. Remove toxicity of toxic proteins/peptides through structural modification, combine with therapeutic drugs to enhance the anti-cancer function of toxins.
  • Delivery strategy development. Effective delivery of venom protein/peptide through nanoparticle encapsulation accelerates anti-cancer treatment.



We can prepare customized services according to customer needs, including information consultation, design and implementation of detailed experimental schemes, etc.

Creative Proteomics provides services related to cancer targeted venom therapy research. We have mature venom toxin protein/peptide separation and purification technology and excellent characterization and analysis technology, and we are a service provider you can rely on for the application of venom to cancer treatment research. If you are interested in any direction of venom research, you can contact us.


  • Ravi K U. Use of Animal Venom Peptides/Toxins in Cancer Therapeutics. Curr Trends Biomedical Eng & Biosci. 2018; 16(4): 555945.
For research use only. Not intended for any clinical use.
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