Loading A Single Toxin with Nanoparticles

Crude venom is a very complex mixture of compounds, some of which may show beneficial effects, while others may show adverse effects. Therefore, the use of isolated compounds with beneficial effects can greatly enhance its potential. Certain toxins in some venoms show a variety of biological and pharmacological activities. Due to their target specificity, they may be developed into biological drugs to treat various diseases. However, despite the great potential of the toxin as a drug, some limitations have prevented its development, such as instability and off-target cytotoxicity. One strategy to overcome these shortcomings is to use nanocarriers to formulate functional toxins.

Nanocarriers can be used to encapsulate pharmacologically active toxins to make them bioavailable for pharmaceutical use. Creative Proteomics provides toxin nanotechnology services to improve the bioavailability and medicinal treatment effects of venom toxins, thereby bringing great potential for possible clinical outcomes.

Service Introduction

Creative Proteomics combine purified toxins from target venoms with nanoparticles and evaluate their medicinal potential, provide ultraviolet-visible spectroscopy, dynamic light scattering, transmission electron microscopy, atomic force microscopy, and zeta potential analysis techniques to characterize the final synthesized nanotoxin. We provide related services in accordance with the general plan, as follows:

• The target toxin is purified from the venom by ion exchange chromatography and reversed-phase high performance liquid chromatography. We guarantee the quality and purity of the toxin.
• Synthesize customized nanoparticles and develop a synthetic method to produce stable nanoparticles under appropriately controlled conditions. The purified toxin is added to the systemized nanoparticle solution, and the appropriate binding is carried out by the adsorption method.
• Use UV-Vis spectrophotometer, dynamic light scattering research, transmission electron microscopy research, atomic force microscopy (AFM) analysis and other methods to characterize the properties of nanoconjugates and optimize the structure.

Applications

Venom toxins may show promising results in fighting various diseases, such as arthritis, Alzheimer's disease, Parkinson's disease, etc. The combination of nanoparticles and venom toxins can be applied in several aspects in this direction:

• Improve the function of toxins
• Reduce toxin toxicity
• Overcome the toxic defects of venom toxin molecules

Advantages

• One-stop service. From the separation and purification of toxins to the characterization of nanoconjugates are all included in our services.
• Comprehensive test reports. Use a variety of characterization methods to detect toxins and nanoparticle conjugates, and deliver products that customers are satisfied with.
• Excellent effect. Through detection optimization, the final sample has good performance.

The applications of venom toxins include disadvantages such as poor chemical stability, low efficiency, and off-target toxicity. Creative Proteomics applies the high specificity and stability of nanoparticles to the transportation of toxins, which can increase the application field of venom toxins and improve the efficiency of medicinal use.

We are always looking for new nanotechnology to bring excellent medicinal effects to venom toxins. If you have relevant development ideas, please contact us-we are happy to help you.

Reference

• Attarde S S, Pandit S V. Anticancer potential of nanogold conjugated toxin GNP-NN-32 from Naja naja venom. Journal of Venomous Animals and Toxins including Tropical Diseases, 2020, 26(3).