Nuclear Magnetic Analysis

Nuclear Magnetic Resonance (NMR) technology is ideal for structural analysis of antibody drugs and plays a uniquely important role in the higher-order structural elucidation of proteins. Creative Proteomics' NMR-based higher-order structural characterization service provides a more streamlined and rapid means of detection. Our advanced detection technology and data analysis system can help clients identify critical structural changes in antibody drugs during drug development and manufacturing to provide accurate information of key quality attributes.

Principles of Nuclear Magnetic Resonance

Nuclear Magnetic Resonance (NMR) provides detailed information on the interactions of atoms and molecules within a molecule, allowing scientists to elucidate the structural and kinetic properties of antibody molecules. The principles of NMR are based on the fact that atomic nuclei possess a property called spin, which generates a tiny magnetic field. When placed in a strong external magnetic field, these nuclear spins align either with or against the field, resulting in two energy levels. NMR takes advantage of the transition between these energy levels by applying radiofrequency pulses and observing the resulting absorption or emission of energy.

Application of Nuclear Magnetic Resonance in Antibody Drug Structural Characterization

Our advanced Nuclear Magnetic Resonance (NMR) technology is a favorable tool to accelerate your antibody drug research and development. It provides you with accurate and detailed informatics of the 3D structure, dynamics and interactions of antibody molecules.

• Determining residue-specific structural information

NMR can determine the precise 3D structure of an antibody drug at the individual amino acid level. By analyzing the nuclear Overhauser effect (NOE) signals, we can provide the internuclear distances between pairs of atoms to determine the spatial arrangement of the protein backbone and side chains.

• Conformational dynamics and flexibility

NMR is sensitive to the conformational dynamics and flexibility of antibody drugs. By measuring relaxation parameters such as longitudinal (T1) and transverse (T2) relaxation times, NMR provides information about the local dynamics and flexibility of residues within the protein structure.

Why Choose Us?

Our NMR (nuclear magnetic resonance) technology offers several advantages for antibody drug characterization. Here are some of the key benefits:

• High-resolution structural analysis: NMR provides high-resolution structural information on antibody drugs, allowing for the determination of their 3D structures and revealing critical details about their conformation, folding, and binding interactions.
• Dynamic studies: NMR can probe the dynamic behavior of antibody drugs, providing insights into their flexibility, conformational changes, and molecular motions.
• Minimal sample requirement: Our NMR technology requires only small amounts of sample, making it suitable for studying limited or precious antibody drug samples.

Service Ordering Process

Creative Proteomics provides you with advanced nuclear magnetic resonance technology and analytical services for the comprehensive characterization of high-level structural information of antibody drugs. Contact us to learn more about nuclear magnetic resonance. We will be happy to assist you.