MALDI-TOF Mass Spectrometry

MALDI-TOF-MS (Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry) is a new type of soft ionization biomass spectrometry, which mainly consists of two parts: Matrix-assisted laser desorption/ionization (MALDI) and time-of-flight (TOF) mass analyzer. It is designed to precisely identify and analyze large molecules with high accuracy. Creative Proteomics provides characterization services based on MALDI-TOF-MS technology. This technology is characterized by high sensitivity, accuracy and resolution, making it a powerful analytical tool for antibody drugs characterization.

Our MALDI-TOF-MS -Based Antibody Drugs Characterization Services

Creative Proteomics offers a wide range of antibody drug characterization services based on high-resolution MALDI-TOF-MS technology, including molecular weight determination, post-translational modification analysis, higher order structure and purity analysis. Our team of experts specializes in mass spectrometry and provides method development and validation services tailored to meet client needs, allowing them to address any challenges encountered during antibody drug characterization.

Our MALDI-TOF-MS technology can be used to analyze the following aspects of antibody drugs:

Molecular Weight Determination

Our MALDI-TOF-MS tech accurately determines the molecular weight of antibody drugs. Through a thorough examination of the results, clients can detect modifications or impurities, verify expected molecular weights, and guarantee drug quality and consistency across all batches.

Post-Translational Modification Analysis

Creative Proteomics' MALDI-TOF-MS technology excels in characterizing post-translational modifications of antibody drugs. Our scientists can assist customers in identifying and quantifying different post-translational modifications, such as glycosylation, deamidation, phosphorylation, and acetylation, by conducting MALDI-TOF-MS analysis of antibody drugs. The assay results obtained can effectively assess the quality and safety of antibody drugs.

Higher Order Structure Analysis

The higher order structure of antibody drugs is an important factor in maintaining their activity and stability. Our high-resolution MALDI-TOF-MS technology accurately measures conformational changes, disulfide bond integrity, and overall folding patterns of antibody drugs, helping customers confirm the quality and stability of their drugs.

Purity Analysis

At Creative Proteomics, we rely on MALDI-TOF-MS technology to detect and analyze antibodies for purity and impurities. Our highly sensitive detectors accurately identify and quantify any impurities in antibody drug manufacturing processes and products, such as truncated or misfolded forms, aggregated or degraded fragments, residual host cell proteins, and other impurities. We utilize cutting-edge mass spectrometry technology and our extensive industry knowledge to guarantee your antibody medication meets all applicable regulatory standards.

Advantages of Our MALDI-TOF-MS Technology

• MS spectra can be obtained to get information about the amino acid composition of the peptide.
• High resolution and sensitivity.
• Fast analysis and high throughput.
• A broad spectrum of molecular weights can be detected.
• There is a tolerance for impurities in the sample.

Creative Proteomics' MALDI-TOF-MS-based services facilitate and expedite antibody therapeutic development via precise and trustworthy characterization data. Our unwavering dedication lies in aiding pharmaceutical, research, and biotech companies towards creating safe and effective antibody treatments for the market. Contact us to learn more about our service and we will be happy to serve you.