In Vitro Pharmacological Tests
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In vitro screening and functional assays are a critical step in the early discovery of antibody drugs, which directly determines their fate. Creative Proteomics offers a range of advanced in vitro antibody drug activity assays to help our customers' in vitro pharmacodynamic screening of antibody drugs go smoothly and obtain molecules with high-quality efficacy.
Introduction of In Vitro Pharmacological Tests
In vitro pharmacological analysis is an important means to validate antibody activity, explore the mechanism of action (MOA) of antibodies, and provide the basis for drug IND filing. In vitro pharmacological analysis needs to be designed according to the characteristics of the antibody, the characteristics of the target to design the appropriate experiments, analysis methods mainly include flow-based, reporter gene, cellular analysis and based on MSD, AlphaLISA, ELISA, Luminex, and other soluble protein analysis.
Our In Vitro Pharmacological Tests
Creative Proteomics provides solutions for cell proliferation, apoptosis, cytokine release, mixed lymphocyte response (MLR), antibody internalization, and neutralizing/blocking antibody validation during antibody drug discovery and development to streamline antibody drug development programs.
Cell proliferation assays are essential for antibody drugs because they help clients gain insight into the drug's effect on cancer cells, immune cells, and other cell types that the drug may target. Creative Proteomics utilizes advanced technologies and methods to determine the effects of antibody drugs on cell proliferation. By measuring the rate of cell growth under the influence of these drugs, we can help clients reliably understand the effectiveness of these drugs.
In the context of antibody drugs, detecting apoptosis can be useful to determine the efficacy and potential side effects of the drug. Antibody drugs often work by inducing apoptosis in target cells. For example, in many cancer treatments, the goal is to selectively induce apoptosis in cancer cells. At Creative Proteomics, we offer a variety of methods to detect apoptosis, including flow cytometry, fluorescence microscopy, DNA fragmentation assays, and Annexin V staining.
Cytokines are a group of proteins and peptides that are crucial in cellular signaling. They regulate a broad range of biological activities including immune and inflammatory responses. By measuring the concentration of specific cytokines in a sample, researchers can gain insight into the drug's effectiveness and the patient's immune response. Creative Proteomics' s scientists use a variety of advanced techniques to measure cytokine release from target cells after co-culture of antibodies and stimulators to help customers meet their specific demands in antibody development.
As a revolutionary method in the immunotherapy field, the mixed lymphocyte response (MLR) assay service for antibody drugs offers a groundbreaking platform for testing the potential of antibody drugs in modulating immune responses. Our MLR service can provide a comprehensive understanding of the immunomodulatory effects of your antibody drugs, facilitating your drug development initiatives.
In recent years, the development of neutralizing or blocking antibodies has become an important aspect of antibody drug investigation. In this test, the ability of the antibody to bind to the target protein and its functional activity are evaluated. These tests help in the quality control of antibody drugs and ensure that the antibody drugs produced are safe, effective and reliable. In addition, it accelerates the launch of new therapies and improves patient outcomes.
Creative Proteomics offers an extremely broad portfolio of platforms and solutions to meet your in vitro pharmacology analysis demands for antibody drug development. Contact us to learn more about our services. We will be happy to serve you.
