Creative Proteomics provides a drug structure confirmation platform to assist customers to confirm the drug structure. The information provided by this service is a decisive factor in ensuring the smooth progress of pharmaceutical, pharmacological and toxicological analysis. Drug structure confirmation service is the foundation of drug research and development.
According to the criteria/specifications of ICH and customer requirements, Creative Proteomics can develop scientific, reasonable and feasible research programs based on the structural characteristics of compounds and drugs. A full range of services can be provided in Creative Proteomics, including the preparation of samples that meet the requirements for structural confirmation and related analysis. Creative Proteomics performed a comprehensive analysis of the results of each test to identify the structure of the test item, including the stereoscopic structure.Creative Proteomics has developed a rapid testing platform suitable for drug manufacturing enterprises and government organizations, which can be used for the drug structure confirmation and issue the analysis report in accordance with the quality assurance/quality control plans and regulations of each country/region and your special requirements.
We can provide you with the following types of drug structure confirmation, including but not limited to:
|DRUG STRUCTURE CAN BE CONFIRMED AT CREATIVE PROTEOMICS
|Conventional methods such as elemental analysis, UV, IR, NMR, MS, thermal analysis, XRPD can be used to confirm the drug structure. For the drugs with special structure, the method of preparing derivatives can be used to indirectly prove the structure of the drugs. For drugs with cis-trans isomerism, especially drugs with different cis-trans structures resulting in different drug stability, physicochemical properties, efficacy and safety, the confirmation of cis-trans structure can be added on the basis of the general confirmation of structure.
|In addition to the confirmation of chemical structure and the determination of specific curl, some other effective methods can be added. The commonly used methods include: Chiral High Pressure Liquid Chromatography (Chiral HPLC) and Gas Chromatography (GC), NMR, XRSD, Optical rotator dispersion (ORD) and Circular Dichroism (CD).
|Organic salts and compounds free from metallic elements
|Two sets of spectrum and test data before and after salt formation can provide sufficient and powerful supplement to structure confirmation.
|Metal salts and complexes
|On the basis of the tests generally required, the addition service can be conducted to reflect the type, form and content of metallic elements in the drug.
Through the determination of the absorbance of the drug solution at different wavelengths in the visible - UV region and the calculation of the absorption coefficient, as well as the identification of the main absorption bands, the information of the possible chromophore, auxochrome and the preliminary connection modes in the drug structure can be obtained, which is of guiding significance for the identification of drugs.
The chemical bonds, functional groups contained in the drugs and their initial connection modes can be inferred through the IR. Even the geometric configuration, crystal type and three-dimensional conformation of the compounds and drugs can be given through this platform.
This technology platform can obtain the type, number, interconnection mode, surrounding chemical environment, and even spatial arrangement of some elements composed of drugs in molecules, and then infer the connection status and initial structure of corresponding functional groups of compounds. Hydrogen nuclear magnetic resonance spectrum (1H-NMR) and carbon nuclear magnetic resonance spectrum (18C-NMR) are commonly used.
At Creative Proteomics, our professional analysts can provide you with improved quality services to support your business. Our professional analysis platform can guarantee consistently accurate and detailed delivery. If the substance or item you want to test is not in the above content, please contact us. Our professionals will customize exclusive solutions for you. Creative Proteomics looks forward to cooperating with you.