Subcellomics Creative Proteomics

Membrane Protein Small Molecule Drug Discovery

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Proteins that span the cell membrane are important to drug targets across most fields of medicine. Over the past 20 years, new technologies and methods have greatly advanced the discovery and development of membrane protein-based drugs. It is reported that more than 60% of current drug targets are based on membrane proteins. In particular, more than one-third of small-molecule drug target proteins come from the G protein-coupled receptor (GPCR), one of several typical membrane protein targets.

Small Molecule Drug Discovery

Our capabilities

Biological processes are a cycled network, and membrane proteins are an important hub in this network, and most drugs achieve their therapeutic effects by interacting with membrane proteins. With an in-depth understanding of membrane proteins, the application of cutting-edge technologies, and experience in drug discovery and development, we are committed to helping our clients develop new and innovative therapies. Creative Proteomics specializes in structural and high-throughput screening technologies for membrane protein-based drug discovery, including small molecule drug discovery.

  • Production of high-quality pure, stable and functional membrane proteins

The discovery of small molecule drugs is based on the availability of a sufficient number of stable, full-length membrane proteins with the function of binding to other proteins or lipid cofactors that constitute the native-like complexes. With a variety of reliable protein expression systems, we can express high-quality membrane proteins with high yields, low toxicity, and relatively high functionality. Our high-quality membrane protein products will significantly reduce unnecessary R&D and time costs for our customers, thereby accelerating progress in membrane protein-based drug development.

  • Membrane protein structure-based drug design

Creative Proteomics has years of experience in protein structure-based drug design. Our capabilities enable deep and comprehensive structure determination based on X-ray crystallography and cryo-electron microscopy (Cryo-EM), and nuclear magnetic resonance (NMR) analysis. Our customized and flexible services can significantly advance small molecule drug discovery.

  • Membrane protein-molecule interaction analysis

We apply surface plasmon resonance (SPR) and membrane protein microarrays to screen a wide range of molecules, including small molecules targeting membrane proteins. This fragment-based drug design serves as a complementary approach to structure-based drug design. Although fragments usually bind with low potency, they form effective interactions with membrane protein targets and thus provide an attractive starting point for the small molecule drug design.

Why choose us?

  • A team of experts in molecular biology, proteomics and biochemistry
  • Cutting-edge technology and advanced platform
  • Strong expertise in membrane protein-based small molecule drug discovery
  • Tailored services from experienced experts

Creative Proteomics is dedicated to offering membrane protein-related services to support you along every stage of drug discovery, ranging from membrane protein production, and hit identification, to candidate drug selection. Our experienced experts will work collaboratively with you to provide customized, results-oriented services and solutions. If you are interested in membrane protein-based small molecule drug discovery and development, please don't hesitate to contact us. We look forward to working with you on your next projects.


  1. Yin, Hang, and Aaron D. Flynn. "Drugging membrane protein interactions." Annual review of biomedical engineering 18 (2016): 51-76.

* For Research Use Only. Not for use in diagnostic procedures.

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