Subcellomics Creative Proteomics

Pancreatic Cancer Exosome Research Solution

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Pancreatic cancer (PC) is a recalcitrant and serious disease due to its complex and latent pathogenesis and the lack of early diagnostic methods. Mortality from PC is rapidly increasing and is expected to be the second most common of all malignancies by 2030. Therefore, researchers are working to investigate the biological mechanism of PC occurrence and development and to develop markers to screen for early curable pancreatic lesions. Increasing evidence suggests that exosomes play a crucial role in tumorigenesis and progression. In recent years, the widespread use of exosomes as biomarkers and drug carriers has made them attractive in the field of PC.

Fig. 1 Various effects of exosomes on PC progression.Fig. 1 Various effects of exosomes on PC progression. (Guo, Xiao-Yu, et al., 2019)

Role of exosomes in PC

Exosomes are nanosized, lipid bilayer membrane-enclosed extracellular vesicles (EVs) ranging in diameter from 30 to 150. These EVs contain functional biomolecules, such as proteins, nucleic acids, and metabolites and can be secreted by a wide range of cell types and cancer cells. Exosomes, as important information transporters between cells, facilitate cell-cell and cell-microenvironment communication in both normal and malignant cells. In the past decade, there has been an increasing number of exosome-related studies that have demonstrated the involvement of exosomes in a variety of cancer-related processes, including tumor cell proliferation, invasion and metastasis, apoptosis inhibition, chemoresistance, and immune tolerance.

Functions of exosomes in pancreatic cancer (PC)
Specific roleFunction description
PC cell proliferationDifferent sources of exosomes have different or even opposite effects on PC cell proliferation, which needs further elucidation and in-depth study.
PC invasion and metastasisExosomes may promote cancer invasion and metastasis by regulating stromal cells, remodeling the extracellular matrix (ECM), and stimulating angiogenesis.
Formation of PC drug resistanceExosomes from the PC or tumor microenvironment can promote drug resistance of PC cancer cells through regulating proteins, associated genes, RNA, and signaling pathways.

Applications of exosomes in PC

  • Exosomes as biomarkers for non-invasive diagnosis of PC, including diagnosis and prognosis
  • Exosomes as therapeutic targets of PC
  • Exosomes as a therapeutic vehicle of PC

Pancreatic cancer exosome research solution at Creative Proteomics

Exploring the biological mechanisms underlying the development of PC will provide a direction for its prevention and treatment. Our experts with years of experience in exosome research can help you plan, conduct, and accelerate your projects. Creative Proteomics provides the following exosome-based services to support PC exosome research, including but not limited to:

Exosome analysis services
Exosome isolation and purificationSucrose gradient centrifugation
Polymer-based exosome enrichment method
Immunomagnetic bead method
Size exclusion chromatography method
Exosome identificationNanoparticle tracking analysis (NTA)
Electron microscopy analysis
Western blot
Exosome marker assayIsolation and enrichment of exosomal CD9, CD63, CD81, TSG101, HSP70 proteins
Exosome surface protein identification and quantitative analysis
Exosome engineeringExosome labeling and tracking
Cargo loading
Engineered exosome production
Cargo loading assessment
Exosomes labeling and trackingExosome fluorescent labeling
Fluorescence exosome purification
Fluorescent exosome concentration labeling
Exosome multiomics analysisExosome proteomics analysis:
Exosome protein profile identification
Exosome protein composition analysis
Exosome protein expression level analysis
Exosome protein differential expression analysis
Exosome metabolomics analysis:
Exosome differential metabolite screening
Qualitative and quantitative analysis of target metabolites/metabolic pathways
Exosome lipidomics analysis:
Exosome lipid composition and level analysis
Differential expression analysis of exosomal lipid molecules
Qualitative and quantitative analysis of targeted lipid molecules
Exosomal biogenesis and identificationOur capabilities will provide strong support for the study of exosome biogenesis and its identification.
Exosomal cargo and loading mechanismOur services can greatly help the study of exosomal cargo and loading mechanism, facilitating the diagnostic and therapeutic applications of exosomes.
Exosome function researchIn vitro analysis of the function of exosomes
In vivo analysis of the function of exosomes

Advantages of our services

  • Preparation of high-purity exosomes
  • High-performance mass spectrometry (MS) system
  • Comprehensive bioinformatics analysis

Creative Proteomics offers a reliable, rapid, and cost-effective one-stop solution for multiple cancer exosome research based on highly stable, reproducible, and sensitive systems for isolation, characterization, identification, and quantitative analysis. Thank you for your interest in our services. Let us know what you are trying to achieve and our team of experts will be in touch with you within one business day to discuss your needs.


  1. Lan, Bin, et al. "The role of exosomes in pancreatic cancer." International Journal of Molecular Sciences 20.18 (2019): 4332.
  2. Guo, Xiao-Yu, et al. "Exosomes and pancreatic diseases: status, challenges, and hopes." International Journal of Biological Sciences 15.9 (2019): 1846.

* For Research Use Only. Not for use in diagnostic procedures.

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