Creative Proteomics, a renowned leader in the field of life sciences, is at the forefront of offering comprehensive services for DNA & RNA drug quantitative analysis. With years of experience and a team of highly skilled experts, we provide cutting-edge solutions that facilitate the advancement of DNA & RNA-based therapies.

Introduction of DNA & RNA Drug Quantitative Analysis

DNA & RNA drugs have emerged as a promising class of therapeutics, revolutionizing the field of precision medicine. These short nucleic acid sequences hold great potential for targeting specific disease-causing genes, regulating gene expression, and modulating cellular processes. To harness the full power of DNA & RNA drugs, accurate and reliable quantitative analysis methods are crucial for their development, characterization, and therapeutic monitoring.

Fig. 1. Hybridization-based LC fluorescence assay quantifying double-stranded siRNAs in mouse plasma. (Wang L, et al., 2016)

Our DNA & RNA Drug Quantitative Analysis Services

Creative Proteomics offers a range of services for the quantitative analysis of DNA and RNA drugs.

qPCR and dPCR Assays

Creative Proteomics offers quantitative polymerase chain reaction (qPCR) and digital polymerase chain reaction (dPCR) assays. These assays are capable of accurately quantifying miRNAs, siRNAs, and lncRNAs, and our platforms incorporate optimized primer and probe designs for robust, highly sensitive, and reproducible quantitation.

Hybridization-based LC-Fluorescence Assays

We offer hybridization-based assays employing fluorescently labeled sequence-specific probes. Our liquid chromatography-fluorescence assay ensures precise quantification of oligonucleotides.

Ligation-based qPCR

Our ligation-based quantitative services detect and quantify target DNA and RNA with high specificity and sensitivity, even at low concentrations. These assays provide accurate quantification, even in complex biological samples.

LC-MS/MS and LC-HRAM Assays

Creative Proteomics utilizes advanced LC-MS/MS and LC-HRAM platforms, ensuring exceptional specificity, precision, and a wide dynamic range. These techniques excel in quantifying modified DNA & RNA and enable simultaneous detection of multiple nucleic acids and metabolites.

Process of Quantitative Analysis

Our quantitative analysis of DNA & RNA drugs follows a systematic approach for precision:

Sample Preparation

We employ optimized methods to extract and purify DNA & RNA from complex biological samples, enhancing assay sensitivity.

Assay Design and Optimization

Experienced scientists design and optimize assays tailored to the target DNA & RNA sequences. This includes primer and probe design, assay technique selection, and reaction condition optimization.

Instrumentation and Analysis

Creative Proteomics utilizes cutting-edge instrumentation, such as qPCR systems, digital PCR platforms, LC-MS/MS, and LC-HRAM systems, to perform quantitative analysis. These instruments enable precise measurement, high sensitivity, and accurate quantification of DNA & RNA drugs.

Data Analysis and Reporting

Our dedicated bioinformatics team employs advanced algorithms and software tools to analyze the obtained data. We provide comprehensive reports, summarizing the results and ensuring a clear interpretation of the quantitative analysis outcomes.

DNA & RNA Drug Quantitative Analysis Application Fields

Our quantitative analysis of DNA & RNA drugs has broad applications across various areas of research, development, and clinical practice.

• Therapeutic Development.
• Precision Medicine.
• Biomarker Research.

Creative Proteomics, with its extensive expertise, cutting-edge technology, and customized solutions, stands as a trusted partner in DNA & RNA drug quantitative analysis. Our comprehensive services, including qPCR, dPCR, hybridization-based LC-Fluorescence assays, and LC-MS/MS/LC-HRAM, ensure accurate and reliable quantification of DNA & RNA therapeutics. Partner with us to unlock the full potential of DNA & RNA-based therapies and drive innovation in precision medicine. Contact us to discuss your DNA & RNA drug quantitative analysis needs and embark on a journey of scientific discovery and therapeutic breakthroughs.