Introduction of DNA & RNA Drug pK_a Determination

pK_a, the acid dissociation constant, is a key property that affects drug solubility, stability and bioavailability. In the study of DNA and RNA drugs, pK_a analyses of these oligonucleotide drugs are particularly important, and these analyses include determining the pH value of the drug when it is present in both ionised and non-ionised forms.

Fig. 1. Deprotonable bases have higher pK_a values in oligonucleotides than in nucleosides. (González-Olvera J. C., et al., 2015)

Our DNA & RNA Drug pK_a Determination Services

Creative Proteomics leverages state-of-the-art technologies and expertise to perform precise pK_a determinations, stability studies, and analytical method development. Our team of seasoned scientists possesses an in-depth understanding of DNA & RNA drug properties, enabling us to deliver pK_a testing results that are both accurate and dependable.

pK_a Determination

Our core service entails the precise determination of pK_a values for your DNA & RNA drug candidates. Utilizing advanced spectroscopy or chromatography techniques, we analyze ionization behavior across a spectrum of pH conditions.

Stability Studies

To achieve successful formulation, it is crucial to comprehend how pH changes impact drug stability. We conduct comprehensive stability studies, assessing the drug's behavior under various conditions, thereby assisting you in designing robust and shelf-stable formulations.

Analytical Method Development

Our team excels in the development of customized analytical methods tailored to your DNA & RNA drug candidates, guaranteeing precise and reproducible pK_a testing.

Bioavailability Prediction

By analyzing pK_a data, we can predict the drug's solubility and bioavailability under different physiological conditions, aiding in dose optimization.

Safety Assessment

Evaluating potential safety risks associated with the drug's ionization state is a critical aspect of our service. Our pK_a testing helps you identify and mitigate adverse effects early in the drug development process.

Process of pK_a Determination

Our services of pK_a determination involve several steps, each aimed at achieving accuracy and reliability.

Consultation

Reach out to our team to discuss your DNA & RNA drug testing needs. Our experts will guide you through the process and suggest a customized testing plan.

Sample Submission

Send us your drug samples, and we'll ensure their proper handling and storage to maintain sample integrity.

pK_a Testing and Analysis

Our scientists will perform pK_a determination, stability studies, and any additional required analyses with precision.

Report Generation

Upon completion of the testing, we'll provide you with a detailed report summarizing the results and interpretations.

Data Discussion

We encourage open communication. Our team will discuss the findings with you, answering any questions you may have.

DNA & RNA Drug pK_a Determination Application Fields

• Bioavailability and Pharmacokinetics.
• Safety and Toxicity.
• Drug Development and Formulation.
• Dose Optimization.
• Drug Repurposing.

Creative Proteomics takes pride in offering top-tier DNA & RNA drug pK_a testing services. With a commitment to excellence, we provide customized solutions, timely results, and expert insights to support your drug development efforts. Trust our specialized expertise and state-of-the-art facilities to help you unlock the potential of your DNA & RNA drug candidates. Contact us today to learn more about our DNA & RNA drug pK_a testing service and how we can assist you in reaching your research goals.