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Xenobiotic Metabolites Analysis

A xenobiotic is a foreign chemical substance found within an organism that is not normally naturally produced by or expected to be present within that organism.

The organism removes xenobiotics by xenobiotic metabolism, consisting of deactivation/activation and excretion of xenobiotics, which happen mostly in the liver. Hepatic enzymes are responsible for the metabolism of xenobiotics by first deactivating/activating them (oxidation, reduction, hydrolysis and/or hydration of the xenobiotic), and then conjugating thesecondary metabolites with glucuronic acid, sulphuric acid, or glutathione, followed by excretion in bile or urine.

Since xenobiotics are foreign chemical compounds in tested organisms, such as dosed drugs in patients, veterinary drugs in treated animals, pesticide residues in wild animals, the xenobiotics and corresponding metabolites are quite important for drug safety evaluation and wildlife refuge. Co-operated with academic organizations and corresponding agencies, Creative Proteomics are experienced in xenobiotic metabolite analysis, metabolite screening, or xenobiotic/metabolite concentration monitoring with advanced analytical platform and professional analysts and technicians.


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