Composition Analysis, which means comprehensive qualitative/quantitative analysis of specific ingredients in the submitted samples with integrated analytical techniques, is often required for synthesis & manufacture of fine chemicals & chemical reagents. In order to make it, it usually needs a series of analytical instruments & devices for ingredient profiling and accurate quantification. The analytical laboratory of Creative Proteomics has established integrated analytical facilities including the following analytical techniques:
Spectroscopy (UV, IR, NMR)
Chromatography(LC, GC, IC)
Mass Spectrometry(MS, MS/MS, GC-MS & LC-MS)
The molecular structures of detected ingredients would be identified with one analytical instrument, and verified by other platforms; then the corresponding concentrations of verified chemicals in complicated chemical reagents would be determined by quantitative analysis. Based on the description of the fine chemicals from our clients, the technical support can issue & develop the optimal analytical proposal. Generally, the typical analytic proposal would be performed in the following steps:
the chemical samples would be analyzed with Fourier Transform infrared spectroscopy(FT IR) & Nuclear Magnetic Resonance spectroscopy(NMR), and the components would be explored, estimated & sorted;
the consequent analytic protocols would be prepared for different fractions;
the information from different fractions would be combined & validated, and experimental spectra would be isolated for comparison with standard spectra in database,such as chemical structural database(including 2,200,000 compounds), and UV spectra database(including 150,000 compounds) and MS spectra database (including 12,000 compounds);
the accurate compositions of identified ingredients would be determined if required.
Because the Composition Analysis can offer qualitative/quantitative description of the samples, it’s widely applied for deformulation & quality control of chemical reagents, and diagnostics of quality problem. Except the analytical instruments above, there are still others, such as Elemental Analyzer & Energy Dispersive Spectroscopy available in Creative Proteomics. Flexible combination of various analytic instruments can be achieved for consequent work based on the analytical results of last step, during the entire analytical procedure. Our experienced tech staff and technicians are glad to discuss the inquiry with you, and provide the optimal procedure for your case at cost-effective rate.
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