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Sulfonamide, also called sulphonamide, sulfa drugs or sulpha drugs, is the basis of several groups of drugs. Sulfonamides are the first antibacterial drugs, but with the advent of antibiotics, the use of sulfonamide in human has become limited. Nowadays, owing to the low cost and their relative efficacy in some common bacterial diseases, sulfonamides are commonly used as veterinary drugs for the treatment of infections and the promotion of growth of livestock and fish. According to the indications and duration of action in the body, the sulfonamides and sulfonamides derivatives can be classified into several types. Although there are many sulfonamide antimicrobials, just a few are used clinically in animals. However, sulfonamide residue in food is an important concern due to the possible risk to human. Many countries have established the allowed maximum residue limits (MRLs) in edible animal tissues and milk. So there is a need to measure it by GC-MS using material labeled with a stable isotope as an internal standard.
Figure 1. The general structure of sulfonamide
As a supplier of isotope labeled products in the industry, Creative Proteomics offers more than 10,000 products labeled with different isotopes of carbon, hydrogen, nitrogen, and oxygen. Creative Proteomics supplies stable isotope labeled and unlabeled sulfonamide, including acetylsulfadimidine, sulfadimidine, sulfamoxole, sulfaphenazole, etc. Custom synthesis of isotope labeled sulfonamides is also available to meet our customers’ research needs.