Nitroimidazoles

Nitroimidazole, an organic compound with the formula O₂NC₃H₂N₂H, refers to a class of antibiotics. Nitroimidazoles can be used as antibiotics for the treatment and prevention of infections caused by anaerobic bacteria with rare resistance in these organisms. Therefore, they play an important role in the treatment of intra-abdominal and gynecologic sepsis, abscesses and tetanus. In addition, they are a class of antibacterial and anticoccidial drugs used for the treatment of cattle, poultry and pigs. However, it is reported that these compounds display mutagenic, carcinogenic and toxic properties. For this reason, the European Union (EU) has prohibited their use as additives in feed for food-producing species and all of them are currently in Annexe IV of the Council Regulation (EC) 2377/90. It is violative to detect nitroimidazoles found in food-producing animals or in products intended for human consumption according to EU regulation. Gas or liquid chromatography coupled with a mass spectrometer can be used for the confirmation and identification of nitroimidazoles.

As a supplier of isotope labeled products in the industry, Creative Proteomics offers more than 10,000 products labeled with different isotopes of carbon, hydrogen, nitrogen, and oxygen. Creative Proteomics supplies stable isotope labeled and unlabeled nitroimidazoles standards, including metronidazole (MNZ), dimetridazole (DMZ), ipronidazole (IPZ), and ronidazole (RNZ). Custom synthesis of isotope labeled nitroimidazoles is also available to meet our customers’ research needs.