Nitrofuran Metabolites

Nitrofurans, whose defining structural component is a furan ring with a nitro group, is a class of broad-spectrum antibiotics or antimicrobials. Nitrofurans include furazolidone (FZD), furaltadone (FTD), nitrofurantoin (NFT) and nitrofurazone (NFZ). Nitrofurans can be used to treat infections caused by bacteria and protozoa through inhibiting glucose metabolism and ribosomal function. In addition, nitrofurans were commonly used as feed additives for growth promotion, and mainly used for livestock, aquaculture, and bee colonies. However, considering the concerns about the carcinogenicity of the drug residues and their potential harmful effects on human health, the European Union has completely prohibited the use of nitrofurans for livestock production. Australia, Japan, USA, Philippines, and Thailand have quickly adopted this prohibition. Nitrofurans have in vivo half-lives of only a few hours and are rapidly metabolized in the body within hours after administration. But their metabolites reside in the animal body for weeks, even months, as protein bound residues. Therefore, they must be identified by their metabolites.

As a supplier of isotope labeled products in the industry, Creative Proteomics offers more than 10,000 products labeled with different isotopes of carbon, hydrogen, nitrogen, and oxygen. Creative Proteomics supplies stable isotope labeled and unlabeled nitrofuran metabolites standards, including 3-amino-2-oxazolidinone (AOZ), 3 amino-5-morpholinomethyl-2-oxazolidinone (AMOZ), semicarbazide (SEM), and 1-aminohydantoin (AHD). Custom synthesis of isotope labeled nitrofuran metabolites is also available to meet our customers’ research needs.